Complex, multimodal behavioral profile of the Homer1 knockout mouse.

Complex, multimodal behavioral profile of the Homer1 knockout mouse. Research Abstract Details 

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Complex, multimodal behavioral profile of the Homer1 knockout mouse. Abstract Text:

P J Jaubert,M S Golub,Y Y Lo,S L Germann,M H Dehoff,P F Worley,S H Kang,M K Schwarz,P H Seeburg,R F Berman,

Proteins of the Homer1 immediate early gene family have been associated with synaptogenesis and synaptic plasticity suggesting broad behavioral consequences of loss of function. This study examined the behavior of male Homer1 knockout (KO) mice compared with wild-type (WT) and heterozygous mice using a battery of 10 behavioral tests probing sensory, motor, social, emotional and learning/memory functions. KO mice showed mild somatic growth retardation, poor motor coordination, enhanced sensory reactivity and learning deficits. Heterozygous mice showed increased aggression in social interactions with conspecifics. The distribution of mGluR5 and N-methyl-D-aspartate receptors (NMDA) receptors appeared to be unaltered in the hippocampus (HIP) of Homer1 KO mice. The results indicate an extensive range of disrupted behaviors that should contribute to the understanding of the Homer1 gene in brain development and behavior.

Complex, multimodal behavioral profile of the Homer1 knockout mouse. Publishing Authors By Initials

PJ Jaubert,MS Golub,YY Lo,SL Germann,MH Dehoff,PF Worley,SH Kang,MK Schwarz,PH Seeburg,RF Berman,

For similar biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research

PUBMED ID PMID:

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Complex, multimodal behavioral profile of the Homer1 knockout mouse. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genes, brain, and behavior

VOLUME: 6

Page Numbers: 141-54

Journal Abbreviation: Genes Brain Behav.

ISSN: 1601-1848

DAY: 3

MONTH: Mar

YEAR: 2007

Complex, multimodal behavioral profile of the Homer1 knockout mouse. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101129617

Complex, multimodal behavioral profile of the Homer1 knockout mouse. Keywords Mesh Terms:

KEYWORDS: Species Specificity

MESH TERMS: metabolism

Chemical & Substance for Abstract: Complex, multimodal behavioral profile of the Homer1 knockout mouse. Information

Substance Name: metabotropic glutamate receptor 5

Registry Number: 0

Grant and Affiliation Information for Complex, multimodal behavioral profile of the Homer1 knockout mouse.

AFFILIATION: Children's Center for Environmental Health & Department of Neurological Surgery, University of California Davis, CA 95616, USA.

Country: England

AGENCY: United States NIEHS

GRANT: 1 P01 ES11269

ACRONYM: ES

MEDLINETA: Genes Brain Behav

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