Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation.

Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. Research Abstract Details 

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Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. Abstract Text:

Acute lung injury (ALI) causes high mortality, but its molecular mechanisms are poorly understood. Acid aspiration is a frequent cause of ALI, leading to neutrophil sequestration, increased permeability, and deterioration of gas exchange. We investigated the role of platelet-neutrophil interactions in a murine model of acid-induced ALI. Acid aspiration induced P-selectin-dependent platelet-neutrophil interactions in blood and in lung capillaries. Reducing circulating platelets or blocking P-selectin halted the development of ALI. Bone marrow chimeras showed that platelet, not endothelial, P-selectin was responsible for the injury. The interaction of platelets with neutrophils and endothelia was associated with TXA(2) formation, with detrimental effects on permeability and tissue function. Activated platelets induced endothelial expression of ICAM-1 and increased neutrophil adhesion. Inhibition of platelet-neutrophil aggregation improved gas exchange, reduced neutrophil recruitment and permeability, and prolonged survival. The key findings were confirmed in a sepsis-induced model of ALI. These findings may translate into improved clinical treatments for ALI.

Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. Publishing Authors By Initials

For similar respiratory tract diseases: lung diseases: respiratory distress syndrome, adult research abstracts see: respiratory tract diseases: lung diseases: respiratory distress syndrome, adult research

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Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of clinical investigation

VOLUME: 116

Page Numbers: 3211-9

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 3

MONTH: Dec

YEAR: 2006

Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7802877

Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. Keywords Mesh Terms:

KEYWORDS: Respiratory Distress Syndrome, Adult

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. Information

Substance Name: Busulfan

Registry Number: 55-98-1

Grant and Affiliation Information for Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation.

AFFILIATION: Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908-1394, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: P01 HL 73361

ACRONYM: HL

MEDLINETA: J Clin Invest

REFSOURCE: J Clin Invest. 2006 Dec;116(12):3106-8

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