Complete response of a patient with advanced gastric cancer, showing Epstein-Barr virus infection, to preoperative chemotherapy with S-1 and cisplatin.

Complete response of a patient with advanced gastric cancer, showing Epstein-Barr virus infection, to preoperative chemotherapy with S-1 and cisplatin. Research Abstract Details 

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Complete response of a patient with advanced gastric cancer, showing Epstein-Barr virus infection, to preoperative chemotherapy with S-1 and cisplatin. Abstract Text:

Tomoko Seya,Noritake Tanaka,Kimiyoshi Yokoi,Noriyuki Ishikawa,Koji Horiba,Yoshikazu Kanazawa,Takeshi Yamada,Michihiro Koizumi,Seiichi Shinji,Hirotake Okazaki,Yoshiharu Ohaki,Toshiyuki Ishiwata,Zenya Naito,Takashi Tajiri,

Here we report the case of a patient with advanced gastric cancer with esophageal invasion who was treated with chemotherapy using S-1 and cisplatin (CDDP) preoperatively. The patient was a 72-year-old woman who was diagnosed with advanced gastric cancer (T3N2M0) with esophageal invasion. S-1 was orally administered at 80 mg/day (60 mg/m(2) per day) on days 1-14 and CDDP was infused at 80 mg/day (60 mg/m(2) per day) on day 8, followed by a 1-week rest. Marked reductions in the sizes of the primary tumor and metastatic lymph nodes around the stomach were observed after two cycles of the therapy. Adverse reactions occurring during the therapy were only grade 2 gastrointestinal disorder and grade 1 leukocytopenia. Radiological and endoscopic examinations before surgery showed that a partial response (PR) had been achieved. The patient underwent curative surgery consisting of total gastrectomy, D2 lymph node dissection, and splenectomy. Her postoperative course was uneventful, without surgical complications. No gastric cancer cells were detected in the primary lesion or lymph nodes by immunohistochemical staining with cytokeratin, confirming a histological complete response (CR). As Epstein-Barr virus-encoded small RNA (EBER) had been detected by in-situ hybridization in the gastric cancer cells of a biopsy specimen, this tumor was diagnosed as an Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC), which was effectively treated with S-1 and cisplatin chemotherapy.

Complete response of a patient with advanced gastric cancer, showing Epstein-Barr virus infection, to preoperative chemotherapy with S-1 and cisplatin. Publishing Authors By Initials

T Seya,N Tanaka,K Yokoi,N Ishikawa,K Horiba,Y Kanazawa,T Yamada,M Koizumi,S Shinji,H Okazaki,Y Ohaki,T Ishiwata,Z Naito,T Tajiri,

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Complete response of a patient with advanced gastric cancer, showing Epstein-Barr virus infection, to preoperative chemotherapy with S-1 and cisplatin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of clinical oncology / Japan

VOLUME: 12

Page Numbers: 472-7

Journal Abbreviation: Int. J. Clin. Oncol.

ISSN: 1341-9625

DAY: 21

MONTH: 12

YEAR: 2007

Complete response of a patient with advanced gastric cancer, showing Epstein-Barr virus infection, to preoperative chemotherapy with S-1 and cisplatin. Information

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LANGUAGE: eng

NlmUniqueID: 9616295

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Grant and Affiliation Information for Complete response of a patient with advanced gastric cancer, showing Epstein-Barr virus infection, to preoperative chemotherapy with S-1 and cisplatin.

AFFILIATION: Department of Surgery, Chiba-Hokusoh Hospital, Nippon Medical School, 1715 Kamagari, Inbamura, Chiba, 270-1694, Japan, seya@nms.ac.jp.

Country: Japan

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MEDLINETA: Int J Clin Oncol

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