Complete genetic linkage can subvert natural selection.

Complete genetic linkage can subvert natural selection. Research Abstract Details 

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Complete genetic linkage can subvert natural selection. Abstract Text:

Philip J Gerrish,Alexandre Colato,Alan S Perelson,Paul D Sniegowski,

The intricate adjustment of organisms to their environment demonstrates the effectiveness of natural selection. But Darwin himself recognized that certain biological features could limit this effectiveness, features that generally reduce the efficiency of natural selection or yield suboptimal adaptation. Genetic linkage is known to be one such feature, and here we show theoretically that it can introduce a more sinister flaw: when there is complete linkage between loci affecting fitness and loci affecting mutation rate, positive natural selection and recurrent mutation can drive mutation rates in an adapting population to intolerable levels. We discuss potential implications of this finding for the early establishment of recombination, the evolutionary fate of asexual populations, and immunological clearance of clonal pathogens.

Complete genetic linkage can subvert natural selection. Publishing Authors By Initials

PJ Gerrish,A Colato,AS Perelson,PD Sniegowski,

For similar genetic processes: selection (genetics) research abstracts see: genetic processes: selection (genetics) research

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Complete genetic linkage can subvert natural selection. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 6266-71

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ISSN: 0027-8424

DAY: 3

MONTH: 04

YEAR: 2007

Complete genetic linkage can subvert natural selection. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

Complete genetic linkage can subvert natural selection. Keywords Mesh Terms:

KEYWORDS: Selection (Genetics)

MESH TERMS: genetics

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Grant and Affiliation Information for Complete genetic linkage can subvert natural selection.

AFFILIATION: Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA. pgerrish@unm.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR06555

ACRONYM: RR

MEDLINETA: Proc Natl Acad Sci U S A

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