Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction.

Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction. Abstract Text:

Kyeong-Man Kim,Marc G Caron,Kyeong-Man Kim,Marc G Caron,Kyeong-Man Kim,Marc G Caron,

beta-arrestin mediates the desensitization of GPCRs and acts as an adaptor molecule to recruit the receptor complex to clathrin-rich regions. Class-A GPCRs subsequently dissociate from beta-arrestin but class-B GPCRs internalize with beta-arrestin in the endocytic vesicles. Here the dopamine D(2) and D(3) receptors, which have similar structural features but different intracellular trafficking properties, were used in an attempt to better understand the structural requirements for the classification of GPCRs. The C-terminus tail of the vasopressin type-2 receptor was added to the ends of D(2)R and D(3)R to increase their affinity to beta-arrestin. A point mutation was introduced into the DRY motif to change their basal activation levels. Among a battery of constructs in which the C-terminus tail and/or DRY motif was altered, class-B behavior was observed with the constructs whose affinities for beta-arrestin were increased complementarily and their signaling was either maintained or regained. In conclusion, the DRY motif and C-terminal tail of the GPCRs determine complementarily their intracellular trafficking behavior by regulating the affinity to beta-arrestin and G protein coupling.

Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction. Publishing Authors By Initials

KM Kim,MG Caron,KM Kim,MG Caron,KM Kim,MG Caron,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 366

Page Numbers: 42-7

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 26

MONTH: 11

YEAR: 2007

Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction.

AFFILIATION: Department of Pharmacology, College of Pharmacy, Chonnam National University, Kwang-Ju 500-757, Republic of Korea.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biochem Biophys Res Commun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction Related Publications

• A beta-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior.
• Acute bacterial prostatitis: heterogeneity in diagnostic criteria and management. Retrospective multicentric analysis of 371 patients diagnosed with acute prostatitis.
• Adrenomedullin signaling is necessary for murine lymphatic vascular development.
• Allergy to multiple local anesthetics.
• Building a collaborative hematology/oncology advanced nursing practice: part I.
• Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction.
• Defective efficacy of retinoic Acid treatment in patients with metastatic thyroid carcinoma.
• Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin.
• Lack of systemic absorption of lidocaine from 5% patches placed on horses.
• Long-term (up to 18 years) effects on GH/IGF-1 hypersecretion and tumour size of primary somatostatin analogue (SSTa) therapy in patients with GH-secreting pituitary adenoma responsive to SSTa.
• MR cholangiopancreatography versus endoscopic sonography in suspected common bile duct lithiasis: a prospective, comparative study.
• Mice heterozygous for adrenomedullin exhibit a more extreme inflammatory response to endotoxin-induced septic shock.
• Neuroblastoma: biology, prognosis, and treatment.
• Palaeontology. Ancient worms in armour.
• Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice.
• Performance of the urine leukocyte esterase and nitrite dipstick test for the diagnosis of acute prostatitis.
• Phase transformation and segregation to lattice defects in ni-base superalloys.
• Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age.
• Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling.
• Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice.
• Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo.
• Role of GSK3beta in behavioral abnormalities induced by serotonin deficiency.
• [Approach to male alcoholism in France. Clinical and therapeutic aspects]
• [Dyspnea in orthopedics (author's transl)]
• [Early mobilization after reduction and retention by pin of fractures of the posterior tarsus]
• [Indications for the orthopedic management of children with cerebral palsy]
• [Management of fungal urinary tract infections]
• [Surgical treatment of discal hernia]
• [Therapeutic indications in scoliosis occurring during growth]
• [Value of noninvasive cardiac function tests in the chronic phase of myocardial infarct]