Complement Factor H Y402H Polymorphism is not Associated with Late-onset Alzheimer's Disease.

Complement Factor H Y402H Polymorphism is not Associated with Late-onset Alzheimer's Disease. Research Abstract Details 

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Complement Factor H Y402H Polymorphism is not Associated with Late-onset Alzheimer's Disease. Abstract Text:

Gillian Hamilton,Petra Proitsi,Julie Williams,Michael O'Donovan,Michael Owen,John Powell,Simon Lovestone,Gillian Hamilton,Petra Proitsi,Julie Williams,Michael O'Donovan,Michael Owen,John Powell,Simon Lovestone,Gillian Hamilton,Petra Proitsi,Julie Williams,Michael O'Donovan,Michael Owen,John Powell,Simon Lovestone,

There is evidence to suggest a role for immune dysfunction in the pathogenesis of Alzheimer's disease, and it has previously been shown that blood plasma levels of the protein complement factor H, a member of the alternative complement pathway, was specifically elevated in people with late-onset Alzheimer's disease. We have genotyped the common complement factor H Y402H polymorphism in a large case-control cohort to investigate association with late-onset Alzheimer's disease susceptibility and find no evidence that this SNP is associated with disease risk. However, it remains possible that another variant in this gene may modify susceptibility for late-onset Alzheimer's disease.

Complement Factor H Y402H Polymorphism is not Associated with Late-onset Alzheimer's Disease. Publishing Authors By Initials

G Hamilton,P Proitsi,J Williams,M O'Donovan,M Owen,J Powell,S Lovestone,G Hamilton,P Proitsi,J Williams,M O'Donovan,M Owen,J Powell,S Lovestone,G Hamilton,P Proitsi,J Williams,M O'Donovan,M Owen,J Powell,S Lovestone,

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Complement Factor H Y402H Polymorphism is not Associated with Late-onset Alzheimer's Disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuromolecular medicine

VOLUME: 9

Page Numbers: 331-4

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ISSN: 1535-1084

DAY: 22

MONTH: 09

YEAR: 2007

Complement Factor H Y402H Polymorphism is not Associated with Late-onset Alzheimer's Disease. Information

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LANGUAGE: eng

NlmUniqueID: 101135365

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Grant and Affiliation Information for Complement Factor H Y402H Polymorphism is not Associated with Late-onset Alzheimer's Disease.

AFFILIATION: MRC Centre for Neurodegeneration, Institute for Psychiatry, Kings College London, Denmark Hill, London, SE5 8AF, UK.

Country: United States

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MEDLINETA: Neuromolecular Med

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