Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation.

Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. Research Abstract Details 

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Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. Abstract Text:

Baisong Liao,Yan Hu,Gary Brewer,

(A+U)-rich elements (AREs) within 3' untranslated regions are signals for rapid degradation of messenger RNAs encoding many oncoproteins and cytokines. The ARE-binding protein AUF1 contributes to their degradation. We identified MYC proto-oncogene mRNA as a cellular AUF1 target. Levels of MYC translation and cell proliferation were proportional to AUF1 abundance but inversely proportional to the abundance of the ARE-binding protein TIAR, a MYC translational suppressor. Both AUF1 and TIAR affected MYC translation via the ARE without affecting mRNA abundance. Altering association of one ARE-binding protein with MYC mRNA in vivo reciprocally affected mRNA association with the other protein. Finally, genetic experiments revealed that AUF1 and TIAR control proliferation by a MYC-dependent pathway. Together, these observations suggest a novel regulatory mechanism where tuning the ratios of AUF1 and TIAR bound to MYC mRNA permits dynamic control of MYC translation and cell proliferation.

Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. Publishing Authors By Initials

B Liao,Y Hu,G Brewer,

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Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Nature structural & molecular biology

VOLUME: 14

Page Numbers: 511-8

Journal Abbreviation: Nat. Struct. Mol. Biol.

ISSN: 1545-9993

DAY: 7

MONTH: 05

YEAR: 2007

Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. Information

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LANGUAGE: eng

NlmUniqueID: 101186374

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Grant and Affiliation Information for Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation.

AFFILIATION: Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, New Jersey 08854, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA052443

ACRONYM: CA

MEDLINETA: Nat Struct Mol Biol

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