Comparison of two therapeutic protocols in patients with antiphospholipid antibodies and recurrent miscarriages.

Comparison of two therapeutic protocols in patients with antiphospholipid antibodies and recurrent miscarriages. Research Abstract Details 

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Comparison of two therapeutic protocols in patients with antiphospholipid antibodies and recurrent miscarriages. Abstract Text:

Katarina Jeremi?,Miroslava Pervulov,Miroslava Gojni?,Jelena Dukanac,Aleksandar Ljubi?,Jelena Stojni?,

AIM: To compare the effects of two therapeutic protocols for the patients with recurrent miscarriages associated with the presence of antiphospholipid (anticardiolipin) antibodies. METHODS: A prospective observational study included 20 patients with antiphospholipid antibodies in the first group who received low-molecular heparin and aspirin. The second group of 20 patients, in addition to this therapy, received immunotherapy (intravenous immunoglobulin). Aspirin was administered at the time of a positive pregnancy test, and low-molecular heparin not before the fetal heart activity registration by ultrasound. Intravenous immunoglobulin was given prior to the conception or at the beginning of the pregnancy. We compared these groups according to the pregnancy outcomes and the occurrence of complications during pregnancy, using standard statistical tests. RESULTS: The rate of positive gestational outcome in the patients treated with aspirin and low-molecular heparin was 85% (17/20), and in the second group it was 90% (18/20). There was no significant difference in pregnancy outcomes between these groups (p > 0.05), except for the occurence of preeclampsia and thrombocytopenia, which were recorded only in the aspirin and low-molecular heparin group, but with no statistical significance (p > 0.05) compared to the second group, which received immunoglobulin additionally. CONCLUSION: There was no significant difference (p > 0.05) in pregnancy outcomes between the two studied therapeutic protocols, but the therapy with aspirin and low-molecular heparin was cheaper and easier to apply than the therapy with immunoglobulins. The results of our study confirmed that the final pathogenic mechanisms in recurrent fetal miscarriages were inflammation and thrombosis of the uteroplacental blood vessels.

Comparison of two therapeutic protocols in patients with antiphospholipid antibodies and recurrent miscarriages. Publishing Authors By Initials

K Jeremi?,M Pervulov,M Gojni?,J Dukanac,A Ljubi?,J Stojni?,

For similar diagnosis: prognosis: pregnancy outcome research abstracts see: diagnosis: prognosis: pregnancy outcome research

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Comparison of two therapeutic protocols in patients with antiphospholipid antibodies and recurrent miscarriages. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vojnosanitetski pregled. Military-medical and phar

VOLUME: 62

Page Numbers: 435-9

Journal Abbreviation:

ISSN: 0042-8450

DAY: 9

MONTH: Jun

YEAR: 2005

Comparison of two therapeutic protocols in patients with antiphospholipid antibodies and recurrent miscarriages. Information

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LANGUAGE: eng

NlmUniqueID: 21530700

Comparison of two therapeutic protocols in patients with antiphospholipid antibodies and recurrent miscarriages. Keywords Mesh Terms:

KEYWORDS: Pregnancy Outcome

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Comparison of two therapeutic protocols in patients with antiphospholipid antibodies and recurrent miscarriages. Information

Substance Name: Heparin

Registry Number: 9005-49-6

Grant and Affiliation Information for Comparison of two therapeutic protocols in patients with antiphospholipid antibodies and recurrent miscarriages.

AFFILIATION: Clinical Center of Serbia, Institute of Gynecology and Obstetrics, Belgrade. jeremicj@hotmail.com

Country: Serbia and Montenegro

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MEDLINETA: Vojnosanit Pregl

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