Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil.

Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil. Research Abstract Details 

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Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil. Abstract Text:

Saunders C Hsu,Monika L Metzger,Melissa M Hudson,Francisco Pedrosa,Mecneide Lins,Marcia Pedrosa,Cynthia Barros,Kaline Maciel,Ching-Hon Pui,Raul C Ribeiro,Scott C Howard,

BACKGROUND: Pediatric Hodgkin lymphoma (HL) has a cure rate of more than 80% in high-income countries (HIC). However, more than 80% of the world's children live in low-income countries (LIC), where the cure rate is often much lower. PROCEDURE: We compared the outcome of HL of 371 patients treated at two pediatric oncology centers in the US to that of 62 patients treated at one center in Recife, Brazil (IMIP) to determine whether the same treatment strategy should be used in both high-income and LIC. The logrank test was used to compare event-free and overall survival. RESULTS: The percentages of patients with unfavorable disease at each center were similar (P = 0.72). Patients with favorable disease at IMIP had estimated 5-year survival rates comparable to those of the US centers (100% and 99%, respectively). Among patients with unfavorable disease, those treated at IMIP had a 5-year event-free survival (EFS) rate of 60%, compared to 78% at the US centers; (P = 0.08). The 5-year survival estimate after relapse was 25% at IMIP versus 61% at the US centers (P = 0.08). The 5-year overall survival for patients with unfavorable disease was 72% at IMIP versus 90% at the US centers (P = 0.01). CONCLUSIONS: Intensive frontline therapy should be considered for patients with unfavorable HL in LIC where the relapse rate is high and the salvage rate is low, provided that supportive care is adequate.

Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil. Publishing Authors By Initials

SC Hsu,ML Metzger,MM Hudson,F Pedrosa,M Lins,M Pedrosa,C Barros,K Maciel,CH Pui,RC Ribeiro,SC Howard,

For similar heterocyclic compounds: alkaloids: indole alkaloids: secologanin tryptamine alkaloids: vinca alkaloids: vincristine research abstracts see: heterocyclic compounds: alkaloids: indole alkaloids: secologanin tryptamine alkaloids: vinca alkaloids: vincristine research

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Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric blood & cancer

VOLUME: 49

Page Numbers: 139-44

Journal Abbreviation:

ISSN: 1545-5009

DAY: 3

MONTH: Aug

YEAR: 2007

Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil. Information

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LANGUAGE: eng

NlmUniqueID: 101186624

Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil. Keywords Mesh Terms:

KEYWORDS: Vincristine

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil. Information

Substance Name: Vinblastine

Registry Number: 865-21-4

Grant and Affiliation Information for Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil.

AFFILIATION: Department of Pediatrics, Division of Pediatric Hematology-Oncology, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, Oregon, USA. hsus@ohsu.edu

Country: United States

AGENCY: United States NCI

GRANT: R01-CA600419

ACRONYM: CA

MEDLINETA: Pediatr Blood Cancer

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