Comparison of the sterilising activities of the nitroimidazopyran PA-824 and moxifloxacin against persisting Mycobacterium tuberculosis.

Comparison of the sterilising activities of the nitroimidazopyran PA-824 and moxifloxacin against persisting Mycobacterium tuberculosis. Research Abstract Details 

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Comparison of the sterilising activities of the nitroimidazopyran PA-824 and moxifloxacin against persisting Mycobacterium tuberculosis. Abstract Text:

Y Hu,A R M Coates,D A Mitchison,Y Hu,A R M Coates,D A Mitchison,

OBJECTIVES: To measure the bactericidal activity of the nitroimidazopyran PA-824 against Mycobacterium tuberculosis, strain H37Rv, in the three Hu/Coates models of bacterial persistence, in comparison with the activity of moxifloxacin (MXF), a drug shown to be likely to shorten treatment in current clinical trials. METHODS: The bactericidal activity of a wide range of PA-824 and MXF concentrations was tested against a 100-day static, starved, anaerobically-adapted culture in Model 1. In Models 2 and 3, rifampicin (RMP) 100 mg/ml was added to the 100-day culture for 5-7 days and bactericidal activities against surviving tolerant bacilli were tested by addition of the test drugs after removal of RMP in Model 2, and during exposure to RMP in Model 3. RESULTS AND DISCUSSION: PA-824 exhibited little bactericidal activity at low concentrations up to 1.25 mug/ml in each of these models, but high concentrations of >/=10 mug/ml showed considerable bactericidal activity, sufficient to kill all bacilli in Model 3, and appreciably greater than with MXF. However, as PA-824 is 94% plasma bound, concentrations of free drug sufficient to reach the zone of high bactericidal activity may not be obtained in cavities of pulmonary tuberculosis.

Comparison of the sterilising activities of the nitroimidazopyran PA-824 and moxifloxacin against persisting Mycobacterium tuberculosis. Publishing Authors By Initials

Y Hu,AR Coates,DA Mitchison,Y Hu,AR Coates,DA Mitchison,

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Comparison of the sterilising activities of the nitroimidazopyran PA-824 and moxifloxacin against persisting Mycobacterium tuberculosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The international journal of tuberculosis and lung

VOLUME: 12

Page Numbers: 69-73

Journal Abbreviation: Int. J. Tuberc. Lung Dis.

ISSN: 1027-3719

DAY: 4

MONTH: Jan

YEAR: 2008

Comparison of the sterilising activities of the nitroimidazopyran PA-824 and moxifloxacin against persisting Mycobacterium tuberculosis. Information

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LANGUAGE: eng

NlmUniqueID: 9706389

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AFFILIATION: Medical Microbiology, Department of Cellular & Molecular Medicine, St George&s, University of London, London, United Kingdom.

Country: France

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MEDLINETA: Int J Tuberc Lung Dis

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