Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs.

Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs. Research Abstract Details 

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Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs. Abstract Text:

Sayer I Al-Azzam,Lawrence Fleckenstein,Kuei-Ju Cheng,Michael T Dzimianski,John W McCall,Sayer I Al-Azzam,Lawrence Fleckenstein,Kuei-Ju Cheng,Michael T Dzimianski,John W McCall,

This study compares plasma disposition kinetics of ivermectin and moxidectin after oral administration to beagle dogs experimentally infected with the filarial parasite, Brugia pahangi. Sixteen dogs were selected and randomly allocated into two groups of eight dogs each. Animals in each group received either ivermectin or moxidectin by oral route at a dose of 250 microg/kg. Blood samples were collected from 0.5 h up to 56 days post-treatment and the plasma was analysed by high performance liquid chromatography (HPLC). The obtained data were analysed by compartmental and non-compartmental pharmacokinetic techniques. Peak plasma concentrations (C(max)) of 234.0 +/- 64.3 ng/ml (mean +/- SD) were obtained for moxidectin and 132.6 +/- 43.0 ng/ml for ivermectin. The terminal elimination half-life was significantly (p<0.01) longer in the moxidectin treated group (621.3 +/- 149.3 h) than for ivermectin treated group (80.3 +/- 29.8 h). A significantly (p< 0.01) larger V(ss)/F was obtained for moxidectin (19.21 +/- 3.61 l/kg) compared with ivermectin (5.35 +/- 1.29 l/kg). The mean estimates of CL/F of moxidectin and ivermectin were 0.0220 +/- 0.00381 and 0.0498 +/- 0.0179 l/h/kg, respectively. The comparative plasma disposition kinetics of ivermectin and moxidectin in dogs is reported for the first time.

Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs. Publishing Authors By Initials

SI Al-Azzam,L Fleckenstein,KJ Cheng,MT Dzimianski,JW McCall,SI Al-Azzam,L Fleckenstein,KJ Cheng,MT Dzimianski,JW McCall,

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Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biopharmaceutics & drug disposition

VOLUME: 28

Page Numbers: 431-8

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ISSN: 0142-2782

DAY: 29

MONTH: Nov

YEAR: 2007

Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs. Information

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LANGUAGE: eng

NlmUniqueID: 7911226

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Grant and Affiliation Information for Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs.

AFFILIATION: College of Pharmacy, Jordan University of Science and Technology, Jordan.

Country: England

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MEDLINETA: Biopharm Drug Dispos

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