Comparison of the antioxidant properties of alpha-tocopherol and alpha-tocopheryl acetate in newborn rabbit lung.

Comparison of the antioxidant properties of alpha-tocopherol and alpha-tocopheryl acetate in newborn rabbit lung. Research Abstract Details 

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Comparison of the antioxidant properties of alpha-tocopherol and alpha-tocopheryl acetate in newborn rabbit lung. Abstract Text:

M Knight,J Cook,J Wispe,R J Roberts,

The antioxidant properties of alpha-tocopherol and alpha-tocopheryl acetate in lung tissue were quantitated in vitro by measurement of thiobarbituric acid (TBA) reactants, pentane production and lipid peroxides following either an iron/ascorbate or a xanthine/xanthine oxidase oxidant stress. Lung homogenates were obtained from newborn rabbits treated intravenously with either 10 or 100 mg/kg of either alpha-tocopherol or alpha-tocopheryl acetate. The animals were killed 5 min after dosing to minimize the conversion of alpha-tocopheryl acetate to alpha-tocopherol. Lung homogenates from animals treated with alpha-tocopherol had decreased concentrations of TBA reactants and pentane production after incubation with either oxidant stress compared to lung homogenate from animals treated with alpha-tocopheryl acetate or vehicle alone. Lipid peroxide concentrations were no different in homogenates from alpha-tocopherol or alpha-tocopheryl acetate treated animals. Correlations between antioxidant activity and tissue concentrations of alpha-tocopherol indicate 50% inhibition is achieved with 30-100 micrograms/g lung tissue. In vitro addition of alpha-tocopherol required concentrations between 100 and 200 micrograms/g to reduce lipid peroxidation by 50%.

Comparison of the antioxidant properties of alpha-tocopherol and alpha-tocopheryl acetate in newborn rabbit lung. Publishing Authors By Initials

M Knight,J Cook,J Wispe,RJ Roberts,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

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Comparison of the antioxidant properties of alpha-tocopherol and alpha-tocopheryl acetate in newborn rabbit lung. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Developmental pharmacology and therapeutics

VOLUME: 10

Page Numbers: 245-64

Journal Abbreviation:

ISSN: 0379-8305

DAY: 19

MONTH: 11

YEAR: 1987

Comparison of the antioxidant properties of alpha-tocopherol and alpha-tocopheryl acetate in newborn rabbit lung. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8003947

Comparison of the antioxidant properties of alpha-tocopherol and alpha-tocopheryl acetate in newborn rabbit lung. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Comparison of the antioxidant properties of alpha-tocopherol and alpha-tocopheryl acetate in newborn rabbit lung. Information

Substance Name: Xanthine Oxidase

Registry Number: EC 1.17.3.2

Grant and Affiliation Information for Comparison of the antioxidant properties of alpha-tocopherol and alpha-tocopheryl acetate in newborn rabbit lung.

AFFILIATION:

Country: SWITZERLAND

AGENCY: United States NIGMS

GRANT: GM 07442

ACRONYM: GM

MEDLINETA: Dev Pharmacol Ther

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