Comparison of the 13C-urea blood test to histology and rapid urease testing in the diagnosis of Helicobacter pylori infection in children.

Comparison of the 13C-urea blood test to histology and rapid urease testing in the diagnosis of Helicobacter pylori infection in children. Research Abstract Details 

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Comparison of the 13C-urea blood test to histology and rapid urease testing in the diagnosis of Helicobacter pylori infection in children. Abstract Text:

Christopher D Jolley,David A Wagner,

OBJECTIVE: Helicobacter pylori infection is commonly investigated in children with abdominal pain. The definitive means of diagnosing infection, histology, requires endoscopy and sedation, making it invasive and expensive. Our objective was to compare histology against a less invasive and safer method, the 13C-urea blood test. PATIENTS AND METHODS: Forty children with abdominal pain undergoing upper endoscopy were randomized into either of 2 dosages of 13C-urea. Several biopsies were taken for histology and rapid urease testing. After endoscopy, each child ingested a randomly assigned dosage of either 75 mg or 125 mg 13C-urea, and blood was withdrawn 30 min later. RESULTS: Irrespective of the dosage of 13C-urea, the 13C-urea blood test performed with high accuracy (89%) when compared against either histology or rapid urease testing. The sensitivity and specificity of the blood test was 83% and 91%, respectively. When the smaller dosage of 13C-urea was used, the accuracy of the blood test was 100% compared with histology. There were no adverse events related to using either dosage of 13C-urea. CONCLUSIONS: The 13C-urea blood test may be comparable with histology in diagnosing H. pylori infection in children, and the smaller dosage of 13C-urea does not adversely affect blood test performance. The 13C-urea blood test is well tolerated in children.

Comparison of the 13C-urea blood test to histology and rapid urease testing in the diagnosis of Helicobacter pylori infection in children. Publishing Authors By Initials

CD Jolley,DA Wagner,

For similar enzymes and coenzymes: enzymes: hydrolases: amidohydrolases: urease research abstracts see: enzymes and coenzymes: enzymes: hydrolases: amidohydrolases: urease research

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Comparison of the 13C-urea blood test to histology and rapid urease testing in the diagnosis of Helicobacter pylori infection in children. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of pediatric gastroenterology and nutritio

VOLUME: 44

Page Numbers: 68-70

Journal Abbreviation: J. Pediatr. Gastroenterol. Nut

ISSN: 1536-4801

DAY: 3

MONTH: Jan

YEAR: 2007

Comparison of the 13C-urea blood test to histology and rapid urease testing in the diagnosis of Helicobacter pylori infection in children. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8211545

Comparison of the 13C-urea blood test to histology and rapid urease testing in the diagnosis of Helicobacter pylori infection in children. Keywords Mesh Terms:

KEYWORDS: Urease

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Comparison of the 13C-urea blood test to histology and rapid urease testing in the diagnosis of Helicobacter pylori infection in children. Information

Substance Name: Urease

Registry Number: EC 3.5.1.5

Grant and Affiliation Information for Comparison of the 13C-urea blood test to histology and rapid urease testing in the diagnosis of Helicobacter pylori infection in children.

AFFILIATION: Department of Pediatrics, University of Florida, Gainesville 32610, USA. jollecd@peds.ufl.edu

Country: United States

AGENCY: United States NIDDK

GRANT: 5 R44 DK057905

ACRONYM: DK

MEDLINETA: J Pediatr Gastroenterol Nutr

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