Comparison of Subcutaneous and Intramuscular Ketamine-Medetomidine With and Without Reversal by Atipamezole in Dutch Belted Rabbits (Oryctolagus cuniculus).

Comparison of Subcutaneous and Intramuscular Ketamine-Medetomidine With and Without Reversal by Atipamezole in Dutch Belted Rabbits (Oryctolagus cuniculus). Research Abstract Details 

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Comparison of Subcutaneous and Intramuscular Ketamine-Medetomidine With and Without Reversal by Atipamezole in Dutch Belted Rabbits (Oryctolagus cuniculus). Abstract Text:

Angelina M Williams,Jeff D Wyatt,Angelina M Williams,Jeff D Wyatt,Angelina M Williams,Jeff D Wyatt,

Forty male Dutch belted rabbits (Oryctolagus cuniculus) enrolled in a minimally invasive pharmacokinetics study were used to compare the effi cacy of an anesthetic combination delivered through 2 injection routes. Rabbits were randomly assigned to 4 groups (n = 10/group) to determine the sedative and physiologic effects of ketamine (25 mg/kg)-medetomidine (0.5 mg/kg) given either intramuscularly (IM) or subcutaneously (SC). Palpebral, pedal, ear pinch, and righting refl exes, as well as cardiopulmonary parameters (heart rate, respiratory rate, and arterial blood oxyhemoglobin saturation), were recorded every 5 min. In addition, the reversal effects of an intravenous dose of atipamezole (1 mg/kg), an a2 adrenoreceptor antagonist, were assessed by comparing the return of the righting refl ex in rabbits given the reversal agent with those that recovered spontaneously. Compared with the IM route, SC ketamine-medetomidine effectively induced chemical restraint with less than a 2-min difference in onset of anesthesia and markedly less resistance (for example, fl inching, kicking, and so forth) during the injection. In all groups, the anesthetic regimen, regardless of the route of administration, provided an adequate level of anesthesia. Reversal with atipamezole improved arterial hemoglobin oxygen saturation for both the SC and IM groups; however, an enhanced rate of recovery from anesthesia was clinically apparent only for animals given the combination by the IM route.

Comparison of Subcutaneous and Intramuscular Ketamine-Medetomidine With and Without Reversal by Atipamezole in Dutch Belted Rabbits (Oryctolagus cuniculus). Publishing Authors By Initials

AM Williams,JD Wyatt,AM Williams,JD Wyatt,AM Williams,JD Wyatt,

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Comparison of Subcutaneous and Intramuscular Ketamine-Medetomidine With and Without Reversal by Atipamezole in Dutch Belted Rabbits (Oryctolagus cuniculus). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the American Association for Laboratory

VOLUME: 46

Page Numbers: 16-20

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ISSN: 1559-6109

DAY: 12

MONTH: Nov

YEAR: 2007

Comparison of Subcutaneous and Intramuscular Ketamine-Medetomidine With and Without Reversal by Atipamezole in Dutch Belted Rabbits (Oryctolagus cuniculus). Information

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LANGUAGE: eng

NlmUniqueID: 101269489

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