[Comparison of perioperative myocardial enzyme changes among congenital, rheumatic and coronary artery diseases]

[Comparison of perioperative myocardial enzyme changes among congenital, rheumatic and coronary artery diseases] Research Abstract Details 

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[Comparison of perioperative myocardial enzyme changes among congenital, rheumatic and coronary artery diseases] Abstract Text:

Chang-chun Chen,Zong-lin Shen,Shang-yi Ji,Zhi-hong Liu,Ying-long Hu,

OBJECTIVE: To observe and compare perioperative myocardial enzyme changes in 107 patients with congenital (CHD, n = 53), rheumatic (RHD, n = 40) and coronary artery (CAD, n = 14) diseases, and to find whether different diseases can affect the release and recovery of myocardial enzymes after heart operations. METHODS: On the day before operation and the 1st, 3rd, 5th and the 8th day after operation, the venous blood was taken to measure the release of myocardial enzymes: aspartate aminotransferase (AST), creatine kinase (CK), MB isoenzyme of creatine kinase (CK-MB), lactate dehydrogenase (LDH) and LDH-1. RESULTS: All the enzymes measured before operation in three groups were in the normal range; their release increased abruptly on the 1st day postoperatively to 2 - 15 times of those before operation; on the 3rd day, they recovered to some degrees, and on the 8th day they recovered to normal in all groups except LDH and LDH-1 in rh and CAD groups. Because the aortic cross-clamp time (CCT) had a good positive correlation to the release of myocardial enzymes, those patients whose CCT was over 60 minutes in three groups were compared revealing that the CCT was not different between three groups (P < 0.05). The release of CK, CK-MB and AST was significantly higher in CHD60 group than those in CHD60 and CAD60 groups, they recovered afterwards; while the release of DH and LDH-1 was higher in CAD60 group than those in CAD60 and in CHD60 groups from the 1st day to the 8th day postoperatively. CONCLUSIONS: The release of all the 5 enzymes measured before operation was in normal range in selected CHD, RHD and CAD patients. The release peak and the recovery order of all enzymes were the same in three groups. The release of CK, CK-MB and AST was higher in CHD60 group than those in RHD60 and CAD60 groups on the 1st day. The release of LDH and LDH-1 was higher in RHD60 group than those in CHD60 and CAD60 groups from the 1st day to the 8th day postoperatively. The shorter the CCT is, the less the release of myocardial enzymes. Using the release of LDH and LDH-1 to evaluate the recovery of myocardial injury after open-heart operations was recommended.

[Comparison of perioperative myocardial enzyme changes among congenital, rheumatic and coronary artery diseases] Publishing Authors By Initials

CC Chen,ZL Shen,SY Ji,ZH Liu,YL Hu,

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[Comparison of perioperative myocardial enzyme changes among congenital, rheumatic and coronary artery diseases] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery

VOLUME: 41

Page Numbers: 600-3

Journal Abbreviation: Zhonghua Wai Ke Za Zhi

ISSN: 0529-5815

DAY: 24

MONTH: Aug

YEAR: 2003

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LANGUAGE: chi

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AFFILIATION: The Department of Cardiac Surgery, Sun Yatsen Cardiovascular Hospital, Shenzhen 518020, China.

Country: China

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MEDLINETA: Zhonghua Wai Ke Za Zhi

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