Comparison of olanzapine to risperidone in substance-abusing individuals with schizophrenia.

Comparison of olanzapine to risperidone in substance-abusing individuals with schizophrenia. Research Abstract Details 

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Comparison of olanzapine to risperidone in substance-abusing individuals with schizophrenia. Abstract Text:

Evaristo Akerele,Frances R Levin,

A 14-week double blind study compared the efficacy of olanzapine to risperidone in reducing marijuana/cocaine craving and use in individuals with schizophrenia. The study consisted of three phases: a two-week assessment phase, a two-week cross-taper phase onto olanzapine/risperidone, and a ten-week period of maintenance on olanzapine/risperidone. The proportion of cocaine-positive urines decreases over time for both groups with a trend for a greater reduction for the olanzapine group compared to risperidone group. In the last six weeks, marijuana craving was more likely for the risperidone group compared to the olanzapine group, although there was no group difference in the proportion of negative marijuana urines. The data suggest some potential for the utility of olanzapine for the treatment of cocaine dependence in individuals with schizophrenia.

Comparison of olanzapine to risperidone in substance-abusing individuals with schizophrenia. Publishing Authors By Initials

E Akerele,FR Levin,

For similar disorders of environmental origin: substance-related disorders research abstracts see: disorders of environmental origin: substance-related disorders research

PUBMED ID PMID:

MEDLINE DATE: 2007 Jul-Aug

Comparison of olanzapine to risperidone in substance-abusing individuals with schizophrenia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal on addictions / American Acad

VOLUME: 16

Page Numbers: 260-8

Journal Abbreviation:

ISSN: 1055-0496

DAY: 3

MONTH: 12

YEAR: 2007

Comparison of olanzapine to risperidone in substance-abusing individuals with schizophrenia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9208821

Comparison of olanzapine to risperidone in substance-abusing individuals with schizophrenia. Keywords Mesh Terms:

KEYWORDS: Substance-Related Disorders

MESH TERMS: urine

Chemical & Substance for Abstract: Comparison of olanzapine to risperidone in substance-abusing individuals with schizophrenia. Information

Substance Name: olanzapine

Registry Number: 132539-06-1

Grant and Affiliation Information for Comparison of olanzapine to risperidone in substance-abusing individuals with schizophrenia.

AFFILIATION: Department of Psychiatry, Harlem Hospital, College of Physicians and Surgeons of Columbia University, New York, New York 10037, USA. ea200@columbia.edu

Country: United States

AGENCY: United States PHS

GRANT: K12 00366

ACRONYM:

MEDLINETA: Am J Addict

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