Comparison of medium- and high-energy collimators for 131I-tositumomab dosimetry.

Comparison of medium- and high-energy collimators for 131I-tositumomab dosimetry. Research Abstract Details 

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Comparison of medium- and high-energy collimators for 131I-tositumomab dosimetry. Abstract Text:

Eugene Mah,Ken M Spicer,Eugene Mah,Ken M Spicer,

Residence time measurements obtained by serial whole-body conjugate-view imaging are commonly used in patient-specific dosimetry for radioimmunotherapy applications. In order to determine the effect of collimator selection on residence time measurements for (131)I, the accuracies of (131)I half-life measurements obtained with multiple gamma-camera and collimator combinations were investigated. METHODS: Serial anterior and posterior whole-body images were acquired over a period of 15 d with 4 different gamma-cameras and medium- or high-energy collimators. Background-corrected geometric mean counts from the images were fitted to a monoexponential curve to determine the half-life of (131)I obtained with the different gamma-camera and collimator combinations. RESULTS: An average half-life of 8.15 d (SD, 0.07 d) was obtained with all gamma-camera and collimator combinations. A half-life of 8.12 d (SD, 0.11 d) was obtained with the high-energy collimators, and a half-life of 8.18 d (SD, 0.04 d) was obtained with the medium-energy collimators. These values are all very close to the (131)I physical half-life of 8.02 d and were not found to be statistically significantly different (P = 0.44). Similar results were obtained for the half-life obtained with single-head gamma-camera configurations (mean half-life, 8.15 d; SD, 0.12 d). The therapeutic (131)I-tositumomab dose resulting from the differences in the measured half-life ranged from 2.58 to 2.6 GBq (69.8-70.4 mCi). CONCLUSION: There is no significant difference in (131)I half-life and residence time measurements obtained with medium- or high-energy collimators in dual-head or single-head imaging configurations.

Comparison of medium- and high-energy collimators for 131I-tositumomab dosimetry. Publishing Authors By Initials

E Mah,KM Spicer,E Mah,KM Spicer,

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Comparison of medium- and high-energy collimators for 131I-tositumomab dosimetry. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of nuclear medicine technology

VOLUME: 35

Page Numbers: 148-53

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ISSN: 0091-4916

DAY: 7

MONTH: Sep

YEAR: 2007

Comparison of medium- and high-energy collimators for 131I-tositumomab dosimetry. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Comparison of medium- and high-energy collimators for 131I-tositumomab dosimetry.

AFFILIATION: Department of Radiology, Medical University of South Carolina, Charleston, SC 29425, USA. maheug@musc.edu

Country: United States

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MEDLINETA: J Nucl Med Technol

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