Comparison of immunogenicity between codon optimized HIV-1 Thailand subtype B gp140 and gp145 vaccines.

Comparison of immunogenicity between codon optimized HIV-1 Thailand subtype B gp140 and gp145 vaccines. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Comparison of immunogenicity between codon optimized HIV-1 Thailand subtype B gp140 and gp145 vaccines. Abstract Text:

Yanmin Wan,Lan Wu,Lianxing Liu,Jianqing Xu,Ying Liu,Yong Liu,Yiming Shao,

HIV-1 pandemic posed an unprecedented challenge to the global health and it is believed that an effective vaccine will be the final solution against HIV-1. HIV-1 envelope is the primary immunogen in developing neutralization antibody based HIV vaccine. To define the suitable Env derived immunogen, we systemically compared the immunogenicity of gp140 and gp145 in a DNA vaccination alone and a prime-boost modalities. Two DNA vaccines and two recombinant Tiantan vaccinia vaccines (rTTV) were constructed for vaccination of female Balb/c mice. Elispot assay was used to read out the T cell immunity and ELISA assay was used to quantify antibody immunity. PLL (poly-L-leucine)-ELISA assay was used in linear antibody epitope mapping. Mice primed with gp145 tended to elicit more Env-specific T cells responses than those primed with gp140, significant difference was observed in DNA immunization alone. The ultimate T cell responses in prime-boost regimen tend to be determined mainly by the priming efficacy. Linear antibody epitope mapping displayed that sera raised by gp145 priming were vigorously reactive to more peptides than that by gp140. Our data demonstrated HIV-1 Thailand B-derived gp145 may raise higher T-cell responses and broader linear peptide-specific antibody responses than gp140 does. However, it remains to be determined that how these observations are relevant to the neutralization of antibody activities.

Comparison of immunogenicity between codon optimized HIV-1 Thailand subtype B gp140 and gp145 vaccines. Publishing Authors By Initials

Y Wan,L Wu,L Liu,J Xu,Y Liu,Y Liu,Y Shao,

For similar viruses: dna viruses: poxviridae: chordopoxvirinae: orthopoxvirus: vaccinia virus research abstracts see: viruses: dna viruses: poxviridae: chordopoxvirinae: orthopoxvirus: vaccinia virus research

PUBMED ID PMID:

MEDLINE DATE:

Comparison of immunogenicity between codon optimized HIV-1 Thailand subtype B gp140 and gp145 vaccines. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Vaccine

VOLUME: 25

Page Numbers: 4949-59

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 26

MONTH: 02

YEAR: 2007

Comparison of immunogenicity between codon optimized HIV-1 Thailand subtype B gp140 and gp145 vaccines. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8406899

Comparison of immunogenicity between codon optimized HIV-1 Thailand subtype B gp140 and gp145 vaccines. Keywords Mesh Terms:

KEYWORDS: Vaccinia virus

MESH TERMS: immunology

Chemical & Substance for Abstract: Comparison of immunogenicity between codon optimized HIV-1 Thailand subtype B gp140 and gp145 vaccines. Information

Substance Name: Vaccines, Synthetic

Registry Number: 0

Grant and Affiliation Information for Comparison of immunogenicity between codon optimized HIV-1 Thailand subtype B gp140 and gp145 vaccines.

AFFILIATION: State Key Laboratory for Infectious Diseases Prevention and Control, National Center for AIDS/STD Control and Prevention (NCAIDS), China CDC, 27 Nanwei Road, Xuanwu District, Beijing 100050, China.

Country: Netherlands

AGENCY: United States NIAID

GRANT: U19 AI 51915

ACRONYM: AI

MEDLINETA: Vaccine

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Comparison of immunogenicity between codon optimized HIV-1 Thailand subtype B gp140 and gp145 vaccines Related Publications

• An audio-visual corpus for speech perception and automatic speech recognition.
• Cloning and characterisation of two natural killer enhancing factor genes (NKEF-A and NKEF-B) in pufferfish, Tetraodon nigroviridis.
• Effects of mycophenolic acid on high glucose-induced expression of TGF-beta and CTGF in mesangial cells.
• Interval mapping of quantitative trait loci for time-to-event data with the proportional hazards mixture cure model.
• Perioperative cimetidine application modulates natural killer cells in patients with colorectal cancer: a randomized clinical study.
• [A prospective cohort study on human immunodeficiency virus and syphilis seroconversion among injecting drug users]
• [Analysis of hla-B locus gene polymorphism in sichuan Yi ethnic group and Xinjiang Uygur ethnic group]
• [Application of near-infrared spectra in the determination of water soluble chloride ion in plant samples]
• [Biological significance of E-cadherin in an inflammatory breast carcinoma cell line]
• [CHEK2 c.1100delC may not contribute to genetic background of hereditary breast cancer from Shanghai of China]
• [Characteristics of metastasis and recurrence following curative resection for colonic carcinoma]
• [Clinical significance of regional lymphadenectomy in radical resection of ductal adenocarcinoma in the pancreatic head]
• [Discrimination of varieties of apple using near infrared spectra based on principal component analysis and artificial neural network model]
• [Effect and mechanism of shenshuai mixture (SM) in promoting repair of kidney in acute renal failure rats]
• [Elevation of IFN-gamma transcription level in peripheral blood mononuclear cells of EIAV vaccinated horses]
• [Expert's Comment]
• [Imaging evaluation and interventional therapy of hepatic metastases from small intestinal leiomyosarcoma]
• [Influence of tumor-associated macrophages on progression and prognosis of nasopharyngeal carcinoma]
• [Obtaining and construction of a novel gene from Schistosoma japonicum by expressed sequence tags]
• [Peripheral blood mutated p53 DNA and its clinical value in human breast cancer]
• [Polymorphic analysis of DYS287 and DYS440 in She ethnic in Zhejiang province China]
• [Recurrence patterns and surgical treatment for recurrent colon cancer after radical resection]
• [Separation of alpha-amino acids and peptides by chelated metal ion affinity chromatography]
• [Study on monitoring and clearing of organophosphate in blood in organophosphate poisoned rats]
• [Study on the nonlinear Raman lidar monitoring the CO2 gas]
• [Study on the reliability and validity of the 66-item version on the gross motor function measure in 0-3 year olds with cerebral palsy]
• [Subtype and sequence analysis of human immunodeficiency virus type-1 strains in Guangdong province]
• [Subtype and sequence analysis of the ENV gene of HIV-1 drug users in Guangdong Pearl River delta.]
• [The biological characteristics of beta glucuronidase cDNA transfected renal cancer cell line GRC 1/betaG]
• [Whole exon 5 and intron 5 replaced by RHD/CE in partial D phenotype DVa (Hus)]