Comparison of IL-6-induced STAT1 activation in different responsive cells.

Comparison of IL-6-induced STAT1 activation in different responsive cells. Research Abstract Details 

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Comparison of IL-6-induced STAT1 activation in different responsive cells. Abstract Text:

Ji-Yan Zhang,Yan Li,Yun-Fang Ren,Bei-Fen Shen,

AIM: To investigate the activation status of signal transducer and activator of transcription 1 (STAT1) induced by interlerkin-6 (IL-6) in different responsive cells. METHODS: Immunoblot analysis was performed with antibodies against STAT1 and tyrosine-phosphorylated STAT1. RESULTS: It's found that IL-6 had growth-promoting effects on 7TD1 and TF1 cells but had little effect on the tyrosine-phosphorylation of STAT1. On the other hand, IL-6 activated STAT1 in a dose and time-dependent manner in M1, R2 and U937 cells which underwent growth arrest and macrophage differentiation upon IL-6 induction. CONCLUSION: These results suggest that IL-6-induced STAT1 activation might be associated with growth-inhibitory effects, and our data might help to explain why IL-6 exerts distinct biological effects in different target cells.

Comparison of IL-6-induced STAT1 activation in different responsive cells. Publishing Authors By Initials

JY Zhang,Y Li,YF Ren,BF Shen,

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Comparison of IL-6-induced STAT1 activation in different responsive cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese jour

VOLUME: 19

Page Numbers: 106-8

Journal Abbreviation: Xi Bao Yu Fen Zi Mian Yi Xue Z

ISSN: 1007-8738

DAY: 20

MONTH: Mar

YEAR: 2003

Comparison of IL-6-induced STAT1 activation in different responsive cells. Information

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LANGUAGE: eng

NlmUniqueID: 101139110

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Grant and Affiliation Information for Comparison of IL-6-induced STAT1 activation in different responsive cells.

AFFILIATION: Department of Molecular Immunology, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850,China.

Country: China

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MEDLINETA: Xi Bao Yu Fen Zi Mian Yi Xue Z

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