Comparison of doxorubicin concentration profiles in radiofrequency-ablated rat livers from sustained- and dual-release PLGA millirods.

Comparison of doxorubicin concentration profiles in radiofrequency-ablated rat livers from sustained- and dual-release PLGA millirods. Research Abstract Details 

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Comparison of doxorubicin concentration profiles in radiofrequency-ablated rat livers from sustained- and dual-release PLGA millirods. Abstract Text:

Feng Qian,Nicholas Stowe,Gerald M Saidel,Jinming Gao,

PURPOSE: To evaluate and compare the local pharmacokinetics of doxorubicin in radiofrequency (rf)-ablated rat livers after interstitial delivery from sustained- and dual-release poly(D,L-lactide-co-glycolide) (PLGA) millirods. METHODS: PLGA millirods with sustained- and dual-release kinetics (burst followed by sustained release) of doxorubicin were implanted in rf-ablated rat livers. Doxorubicin release kinetics in vivo were measured from explanted millirods by UV-Vis spectrophotometer over 8 days. Spatial distribution of doxorubicin in liver tissues was measured by fluorescence imaging. RESULTS: In the initial 24 h after millirod implantation, dual-release millirods released significantly more doxorubicin into liver tissues than the sustained millirods. Subsequently, both types of millirods provided comparable sustained-release kinetics over 8 days. With dual-release millirods, doxorubicin concentration and penetration distance in liver tissue increased more rapidly. To reach 30 microg/g doxorubicin concentration at the ablation boundary (targeted site of action), the time required was 6 days and 1.5 days for sustained- and dual-release millirods, respectively. CONCLUSIONS: Compared with sustained-release millirods, dual-release millirods provide a quick concentration elevation and sustaining of the drug concentration at the ablation boundary. Additionally, the steady-state drug concentration agrees well with model predictions based on previously determined transport parameters, which demonstrates the feasibility of rational design of drug formulations in polymer millirods.

Comparison of doxorubicin concentration profiles in radiofrequency-ablated rat livers from sustained- and dual-release PLGA millirods. Publishing Authors By Initials

F Qian,N Stowe,GM Saidel,J Gao,

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Comparison of doxorubicin concentration profiles in radiofrequency-ablated rat livers from sustained- and dual-release PLGA millirods. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Pharmaceutical research

VOLUME: 21

Page Numbers: 394-9

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 8

MONTH: Mar

YEAR: 2004

Comparison of doxorubicin concentration profiles in radiofrequency-ablated rat livers from sustained- and dual-release PLGA millirods. Information

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LANGUAGE: eng

NlmUniqueID: 8406521

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Grant and Affiliation Information for Comparison of doxorubicin concentration profiles in radiofrequency-ablated rat livers from sustained- and dual-release PLGA millirods.

AFFILIATION: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01-CA-90696

ACRONYM: CA

MEDLINETA: Pharm Res

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