Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA study.

Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA study. Research Abstract Details 

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Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA study. Abstract Text:

C Alex McMahan,Samuel S Gidding,Gray T Malcom,Pamela J Schreiner,Jack P Strong,Richard E Tracy,O Dale Williams,Henry C McGill, ,

BACKGROUND: Disease is sometimes best studied by examination of tissue obtained from autopsied individuals. Results derived from autopsied persons are considered biased because many factors influence the decision to perform an autopsy, and variables measured postmortem may be affected by changes immediately prior to death and emergency medical treatment. METHODS: The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study measured coronary heart disease risk factors postmortem in autopsied young adults 23-34 years of age dying from external causes (accidents, homicides, suicides). The Coronary Artery Risk Development in Young Adults (CARDIA) study measured risk factors in living subjects of similar ages. RESULTS: Within sex, race, and age groups, the differences in body mass index between PDAY and CARDIA were significant but small. The prevalences of hyperglycemia/diabetes within sex, race, and age groups were similar in PDAY and CARDIA; overall, blacks in PDAY, but not in CARDIA, had a higher prevalence than whites. Serum lipoprotein concentrations were slightly and significantly higher and significantly more variable in PDAY subjects than in CARDIA subjects; the greater variability was interpreted as due primarily to emergency medical treatment. Prevalences of smoking and hypertension were substantially higher in PDAY subjects. CONCLUSIONS: Although there were statistically significant differences, the overall similarity of the risk factors in the two studies supports the validity of investigating associations of risk factors measured postmortem with anatomically determined arterial lesions in autopsied young adults dying from external causes. The greater variability in postmortem serum measurements attenuates but does not obscure associations.

Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA study. Publishing Authors By Initials

CA McMahan,SS Gidding,GT Malcom,PJ Schreiner,JP Strong,RE Tracy,OD Williams,HC McGill, ,

For similar geographic locations: americas: north america: united states research abstracts see: geographic locations: americas: north america: united states research

PUBMED ID PMID:

MEDLINE DATE: 2007 May-Jun

Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA study. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cardiovascular pathology : the official journal of

VOLUME: 16

Page Numbers: 151-8

Journal Abbreviation: Cardiovasc. Pathol.

ISSN: 1054-8807

DAY: 22

MONTH: 02

YEAR: 2007

Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA study. Information

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LANGUAGE: eng

NlmUniqueID: 9212060

Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA study. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: epidemiology

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Grant and Affiliation Information for Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA study.

AFFILIATION: Department of Pathology, The University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. mcmahan@uthscsa.edu

Country: United States

AGENCY: United States NHLBI

GRANT: N01-HC-95095

ACRONYM: HC

MEDLINETA: Cardiovasc Pathol

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