Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea.

Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. Abstract Text:

Maria E Otto,Marek Belohlavek,Abel Romero-Corral,Apoor S Gami,Gregory Gilman,Anna Svatikova,Raouf S Amin,Francisco Lopez-Jimenez,Bijoy K Khandheria,Virend K Somers,

Obstructive sleep apnea (OSA) and obesity have been linked to systolic and diastolic dysfunction of the left ventricle. Right ventricular function is poorly understood in the 2 clinical conditions. Data from this study show that otherwise healthy obese patients with OSA had increased an left atrial volume index compared with similarly obese patients without OSA (16.3 +/- 1.2 ml/m in obese patients without OSA vs 20.2 +/- 1.0 ml/m in those with OSA, p = 0.02) and altered diastolic function reflected by changes in mitral annular late diastolic velocity (-5.7 +/- 0.7 cm/s in obese patients without OSA vs -7.3 +/- 0.7 cm/s in those with OSA, p = 0.007), mitral annular early diastolic velocity (-7.9 +/- 0.6 cm/s in obese patients without OSA vs -6.4 +/- 0.3 cm/s in those with OSA, p = 0.05), and early to late diastolic annular ratio >1 (82% of obese patients without OSA vs 26% of those with OSA, p = 0.001), which may be signs of early subclinical impairment of cardiac function. Importantly, healthy obese subjects had similarly increased left ventricular mass compared with obese patients with OSA but normal diastolic function and left atrial size. There was a trend toward abnormal right ventricular filling in patients with OSA, measured by altered superior vena cava diastolic velocity during expiration (-15 +/- 2 cm/s in obese patients without OSA vs -10 +/- 3 cm/s in those with OSA, p = 0.2) and a tendency toward diastolic dysfunction reflected by decreased lateral tricuspid annular early diastolic velocity (-7.2 +/- 0.5 cm/s in obese patients without OSA vs -6.1 +/- 0.5 cm/s in those with OSA, p = 0.1) beyond that seen in obesity alone. In conclusion, OSA independent of obesity may induce cardiac changes that could predispose to atrial fibrillation and heart failure.

Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. Publishing Authors By Initials

ME Otto,M Belohlavek,A Romero-Corral,AS Gami,G Gilman,A Svatikova,RS Amin,F Lopez-Jimenez,BK Khandheria,VK Somers,

For similar cardiovascular system: blood vessels: veins: venae cavae: vena cava, superior research abstracts see: cardiovascular system: blood vessels: veins: venae cavae: vena cava, superior research

PUBMED ID PMID:

MEDLINE DATE:

Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of cardiology

VOLUME: 99

Page Numbers: 1298-302

Journal Abbreviation:

ISSN: 0002-9149

DAY: 20

MONTH: 03

YEAR: 2007

Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 207277

Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. Keywords Mesh Terms:

KEYWORDS: Vena Cava, Superior

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea.

AFFILIATION: Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

Country: United States

AGENCY: United States NCRR

GRANT: M01-RR00585

ACRONYM: RR

MEDLINETA: Am J Cardiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea Related Publications

• Association between plasma adiponectin levels and unstable coronary syndromes.
• Blood and urine levels following intramuscular administration of potassium penicillin V.
• CPAP treatment for obstructive sleep apnoea in heart failure: expectations unmet.
• Cardiomyopathy in Africa: heredity versus environment.
• Combined activation and deactivation of visual cortex during tactile sensory processing.
• Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea.
• Consumer health education: Where are we? Where are we going?
• Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
• Effect of dimercaprol in acute iron poisoning.
• Esophageal adenocarcinoma developing above an Angelchik prosthesis.
• Evaluating the need for adenotonsillectomy.
• From reform to relativism: commentary.
• Leptin and vascular function: Friend or foe?
• Microarray studies of genomic oxidative stress and cell cycle responses in obstructive sleep apnea.
• Nutritionally regulated biomarkers for breast cancer.
• Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation.
• Pain in its environmental context: implications for designing environments to enhance pain control.
• Performance-related pay for hospital consultants.
• Question and answer. Solid-column single contrast barium enema after failed colonoscopy.
• Regulation of rod GTP binding protein by guanine nucleotides.
• Risk assessment for environmental health.
• Sleep apnea and hypertension: interactions and implications for management.
• Some available prescriptions for otitis externa.
• Succinylcholine (succinoylcholine), muscle-relaxant of short action.
• The Federal health viewpoint.
• The malpractice controversy and the quality of patient care.
• The unscheduled adenotonsillectomy.
• Trauma to otolaryngic structures.
• Use of ethylenediurea (EDU) to ameliorate ozone effects on purple coneflower (Echinacea purpurea).
• Visual topography of human intraparietal sulcus.