Comparison of bronchodilatory properties of transdermal and inhaled long-acting beta(2)-agonists.

Comparison of bronchodilatory properties of transdermal and inhaled long-acting beta(2)-agonists. Research Abstract Details 

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Comparison of bronchodilatory properties of transdermal and inhaled long-acting beta(2)-agonists. Abstract Text:

T Yamagata,T Hirano,H Sugiura,S Yanagisawa,T Ichikawa,K Ueshima,K Akamatsu,M Nakanishi,K Matsunaga,Y Minakata,M Ichinose,

BACKGROUND: Regular use of long-acting bronchodilators is recommended for symptomatic COPD patients. A transdermal type of beta(2)-agonist, tulobuterol, was recently developed. This agent shows the pharmacokinetic property of a sustained serum concentration for 24h. However, little has been reported about the bronchodilatory properties of this agent. OBJECTIVES: The aim of the present study was to compare the bronchodilatory action of transdermal beta(2)-agonist tulobuterol with that of inhaled long-acting beta(2)-agonist salmeterol. METHODS: An open-label, randomized crossover study was performed. Eleven patients with stable COPD were enrolled in the study. Tulobuterol (2mg/day) or salmeterol (50mug, twice daily) was administered in a randomized, crossover manner. Forced expiratory volume in 1s (FEV(1)), forced vital capacity (FVC) and inspiratory capacity (IC) were measured before administration, every 2h from 12 to 24h, and at 36h after the initial administration. RESULTS: Transdermal beta(2)-agonist tulobuterol showed an improvement in FEV(1), FVC and IC after dosing compared with those at baseline. Salmeterol also improved all parameters of FEV(1), FVC and IC, and showed a greater improvement compared with the transdermal beta(2)-agonist tulobuterol (p<0.05). The values of the area under the curve (AUC) of FEV(1), FVC and IC during the administration of tulobuterol were 2.98+/-1.05, 1.81+/-0.98, 0.75+/-0.85Lh, respectively, and during the administration of salmeterol they were 6.39+/-1.12, 6.61+/-1.34, 4.28+/-0.91Lh, respectively. CONCLUSION: The transdermal beta(2)-agonist tulobuterol showed bronchodilatory action for at least 24h by once daily administration. However, its bronchodilatory potency was about three times less than that of the inhaled beta(2)-agonist salmeterol.

Comparison of bronchodilatory properties of transdermal and inhaled long-acting beta(2)-agonists. Publishing Authors By Initials

T Yamagata,T Hirano,H Sugiura,S Yanagisawa,T Ichikawa,K Ueshima,K Akamatsu,M Nakanishi,K Matsunaga,Y Minakata,M Ichinose,

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Comparison of bronchodilatory properties of transdermal and inhaled long-acting beta(2)-agonists. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pulmonary pharmacology & therapeutics

VOLUME: 21

Page Numbers: 160-5

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ISSN: 1094-5539

DAY: 5

MONTH: 06

YEAR: 2007

Comparison of bronchodilatory properties of transdermal and inhaled long-acting beta(2)-agonists. Information

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LANGUAGE: eng

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AFFILIATION: Third Department of Internal Medicine, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama 641-8509, Japan.

Country: England

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MEDLINETA: Pulm Pharmacol Ther

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