Comparison of adenoviruses from species B, C, e, and f after intravenous delivery.

Comparison of adenoviruses from species B, C, e, and f after intravenous delivery. Research Abstract Details 

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Comparison of adenoviruses from species B, C, e, and f after intravenous delivery. Abstract Text:

Daniel Stone,Ying Liu,Zong-Yi Li,Sebastian Tuve,Robert Strauss, Lieber,Daniel Stone,Ying Liu,Zong-Yi Li,Sebastian Tuve,Robert Strauss, Lieber,Daniel Stone,Ying Liu,Zong-Yi Li,Sebastian Tuve,Robert Strauss,André Lieber,

Recent attempts to circumvent the limitations of adenovirus (Ad) vectors derived from species C serotype Ad5 have focused on the use of alternative human serotypes. These new serotypes have multiple benefits including a low prevalence of neutralizing antibodies in humans and alternate tropisms. To investigate the characteristics of alternatives to Ad5 vectors, we compared the biodistribution and safety of Ads from species B (Ad3, 11p, 35), C (Ad5), E (Ad4), and F (Ad41), or chimeric Ad5 viruses containing the Ad11 or Ad35 fibers (Ad5/11 and Ad5/35), after intravenous (IV) delivery into hCD46 transgenic mice. Our data suggest that (i) mechanisms of cell and tissue sequestration differ; (ii) levels of sequestration to lung, liver, or spleen do not correlate with toxicity; (iii) delivery of all serotypes causes activation of coagulation, possibly through platelet interaction; (iv) despite binding to the same receptor in vitro, Ad serotypes act differently in vivo; and (v) platelet depletion affects blood clearance, organ sequestration and chemokine/cytokine release of some, but not all Ad serotypes. Overall, our data indicate that Ad5-based vectors are relatively safe as compared to other serotypes. This data should be taken into consideration in future studies about the clinical use of Ad vectors.Molecular Therapy (2007) 15 12, 2146-2153. doi:10.1038/sj.mt.6300319.

Comparison of adenoviruses from species B, C, e, and f after intravenous delivery. Publishing Authors By Initials

D Stone,Y Liu,ZY Li,S Tuve,R Strauss,A Lieber,D Stone,Y Liu,ZY Li,S Tuve,R Strauss,A Lieber,D Stone,Y Liu,ZY Li,S Tuve,R Strauss,A Lieber,

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Comparison of adenoviruses from species B, C, e, and f after intravenous delivery. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular therapy : the journal of the American So

VOLUME: 15

Page Numbers: 2146-53

Journal Abbreviation: Mol. Ther.

ISSN: 1525-0016

DAY: 25

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: 1Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington, USA.

Country: United States

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