Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data.

Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data. Research Abstract Details 

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Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data. Abstract Text:

Thomas E Yankeelov,Greg O Cron,Christina L Addison,Julia C Wallace,Ruth C Wilkins,Bruce A Pappas,Giles E Santyr,John C Gore,

Models have been developed for analyzing dynamic contrast-enhanced (DCE)-MRI data that do not require measurements of the arterial input function (AIF). In this study, experimental results obtained from a reference region (RR) analysis are compared with results of an AIF analysis in the same set of five animals (four imaged twice, yielding nine data sets), returning estimates of the volume transfer constant (Ktrans) and the extravascular extracellular volume fraction (ve). Student's t-test values for comparisons of Ktrans and ve between the two models were 0.14 (P=0.88) and 0.85 (P>0.4), respectively (where the high P-values indicate no significant difference between values derived from the two models). Linear regression analysis indicated there was a correlation between Ktrans extracted by the two methods: r2=0.80, P=0.001 (where the low P-value indicates a significant linear correlation). For ve there was no such correlation (r2=0.02). The mean (absolute) percent difference between the models was 22.0% for Ktrans and 28.1% for ve. However, the RR parameter values were much less precise than the AIF method. The mean SDs for Ktrans and ve for the RR analysis were 0.024 min-1 and 0.06, respectively, vs. 0.002 min-1 and 0.03 for AIF analysis.

Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data. Publishing Authors By Initials

TE Yankeelov,GO Cron,CL Addison,JC Wallace,RC Wilkins,BA Pappas,GE Santyr,JC Gore,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred f344 research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred f344 research

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Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Magnetic resonance in medicine : official journal

VOLUME: 57

Page Numbers: 353-61

Journal Abbreviation:

ISSN: 0740-3194

DAY: 3

MONTH: Feb

YEAR: 2007

Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data. Information

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LANGUAGE: eng

NlmUniqueID: 8505245

Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred F344

MESH TERMS: blood supply

Chemical & Substance for Abstract: Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data. Information

Substance Name: Gadolinium DTPA

Registry Number: 80529-93-7

Grant and Affiliation Information for Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data.

AFFILIATION: Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232-2310, USA. yankeelov@vanderbilt.edu

Country: United States

AGENCY: United States NIBIB

GRANT: 1K25EB005936-01

ACRONYM: EB

MEDLINETA: Magn Reson Med

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