Comparison of (99m)Tc-annexin A5 with (18)F-FDG for the detection of atherosclerosis in ApoE-/- mice.

Comparison of (99m)Tc-annexin A5 with (18)F-FDG for the detection of atherosclerosis in ApoE-/- mice. Research Abstract Details 

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Comparison of (99m)Tc-annexin A5 with (18)F-FDG for the detection of atherosclerosis in ApoE-/- mice. Abstract Text:

Yan Zhao,Yuji Kuge,Songji Zhao,Koichi Morita,Masayuki Inubushi,H William Strauss,Francis G Blankenberg,Nagara Tamaki,Yan Zhao,Yuji Kuge,Songji Zhao,Koichi Morita,Masayuki Inubushi,H William Strauss,Francis G Blankenberg,Nagara Tamaki,Yan Zhao,Yuji Kuge,Songji Zhao,Koichi Morita,Masayuki Inubushi,H William Strauss,Francis G Blankenberg,Nagara Tamaki,

PURPOSE: (99m)Tc-annexin A5, a marker of ongoing apoptosis, and (18)F-FDG, a marker of the increased metabolism of inflammatory cells, are supposed to be useful in the detection of metabolically active atheroma. This study reports a comparison of the intralesional distribution of these tracers in relation to lesion development in ApoE-/- mice. METHODS: Male ApoE-/- mice (n = 12-14/group) were maintained on a Western-type diet after the age of 5 weeks. At 25 weeks, (99m)Tc-annexin A5 or (18)F-FDG was injected and the aortas were harvested for autoradiography (ARG) and Oil Red O staining. Regional radioactivity accumulation was compared in relation to the Oil Red O staining score (ranging from 0 to 3, a semiquantitative parameter for evaluating lesion development). RESULTS: Both (99m)Tc-annexin A5 and (18)F-FDG showed preferential uptake into atherosclerotic lesions, with higher uptake levels for (18)F-FDG (mean, 56.07 %IDxkg/m(2)) than for (99m)Tc-annexin A5 (mean, 10.38 %IDxkg/m(2)). The regional uptake levels of each tracer correlated with the Oil Red O staining score (r = 0.65, p < 0.05 for (99m)Tc-annexin A5; r = 0.56, p < 0.05 for (18)F-FDG). The uptake ratios of advanced lesions (score >0.5) to early lesions (score <0.5) were significantly higher for (99m)Tc-annexin A5 than for (18)F-FDG (f = 4.73, p = 0.03). CONCLUSION: Both (99m)Tc-annexin A5 and (18)F-FDG accumulate in atherosclerotic lesions and correlate with the severity of each lesion. The higher absolute uptake levels of (18)F-FDG may be advantageous for lesion detection, whereas the preferential uptake of (99m)Tc-annexin A5 in advanced lesions may be a useful indicator of late-stage lesions or vulnerable plaque transformation.

Comparison of (99m)Tc-annexin A5 with (18)F-FDG for the detection of atherosclerosis in ApoE-/- mice. Publishing Authors By Initials

Y Zhao,Y Kuge,S Zhao,K Morita,M Inubushi,HW Strauss,FG Blankenberg,N Tamaki,Y Zhao,Y Kuge,S Zhao,K Morita,M Inubushi,HW Strauss,FG Blankenberg,N Tamaki,Y Zhao,Y Kuge,S Zhao,K Morita,M Inubushi,HW Strauss,FG Blankenberg,N Tamaki,

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Comparison of (99m)Tc-annexin A5 with (18)F-FDG for the detection of atherosclerosis in ApoE-/- mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of nuclear medicine and molecular

VOLUME: 34

Page Numbers: 1747-55

Journal Abbreviation: Eur. J. Nucl. Med. Mol. Imagin

ISSN: 1619-7070

DAY: 17

MONTH: 04

YEAR: 2007

Comparison of (99m)Tc-annexin A5 with (18)F-FDG for the detection of atherosclerosis in ApoE-/- mice. Information

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LANGUAGE: eng

NlmUniqueID: 101140988

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AFFILIATION: Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, 060-8638, Japan, natamaki@med.hokudai.ac.jp.

Country: Germany

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MEDLINETA: Eur J Nucl Med Mol Imaging

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