Comparison between a single dose of goserelin (depot) and multiple daily doses of leuprolide acetate for pituitary suppression in IVF treatment: a clinical endocrinological study of the ovarian response.

Comparison between a single dose of goserelin (depot) and multiple daily doses of leuprolide acetate for pituitary suppression in IVF treatment: a clinical endocrinological study of the ovarian response. Research Abstract Details 

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Comparison between a single dose of goserelin (depot) and multiple daily doses of leuprolide acetate for pituitary suppression in IVF treatment: a clinical endocrinological study of the ovarian response. Abstract Text:

PURPOSE: Compare the efficacy and safety of two different GnRHa, used for pituitary suppression in IVF cycles. METHODS: A total of 292 patients using depot goserelin (Group 1) and 167 using daily leuprolide acetate (Group 2) were compared. Days required to achieve pituitary function suppression, duration of ovarian stimulation, total dose of HMG, number of aspirated follicles, number of oocytes retrieved, and presence of functional ovarian cyst were analyzed. RESULTS: The time taken to achieve downregulation was similar. The mean number of ampoules used for superovulation was higher in Group 1; however, this difference was observed only for patients >40 years old that started GnRHa in the follicular phase. There was no difference between the two groups in the duration of superovulation, in the number of follicles aspirated, and the number of oocytes retrieved. In the group of patients with >40 years the incidence of ovarian cysts was higher in Group 2. CONCLUSIONS: Both routes of GnRHa have similar effects for pituitary suppression and ovulation induction in assisted reproductive technology. Therefore the long-acting GnRHa is an excellent option, as only a single subcutaneous dose is necessary, decreasing the risk of the patient to forget its use and, most important, it does not interfere in the patient's quality of life.

Comparison between a single dose of goserelin (depot) and multiple daily doses of leuprolide acetate for pituitary suppression in IVF treatment: a clinical endocrinological study of the ovarian response. Publishing Authors By Initials

For similar endocrine system: endocrine glands: pituitary gland research abstracts see: endocrine system: endocrine glands: pituitary gland research

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Comparison between a single dose of goserelin (depot) and multiple daily doses of leuprolide acetate for pituitary suppression in IVF treatment: a clinical endocrinological study of the ovarian response. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Journal of assisted reproduction and genetics

VOLUME: 19

Page Numbers: 313-8

Journal Abbreviation: J. Assist. Reprod. Genet.

ISSN: 1058-0468

DAY: 18

MONTH: Jul

YEAR: 2002

Comparison between a single dose of goserelin (depot) and multiple daily doses of leuprolide acetate for pituitary suppression in IVF treatment: a clinical endocrinological study of the ovarian response. Information

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LANGUAGE: eng

NlmUniqueID: 9206495

Comparison between a single dose of goserelin (depot) and multiple daily doses of leuprolide acetate for pituitary suppression in IVF treatment: a clinical endocrinological study of the ovarian response. Keywords Mesh Terms:

KEYWORDS: Pituitary Gland

MESH TERMS: physiology

Chemical & Substance for Abstract: Comparison between a single dose of goserelin (depot) and multiple daily doses of leuprolide acetate for pituitary suppression in IVF treatment: a clinical endocrinological study of the ovarian response. Information

Substance Name: Goserelin

Registry Number: 65807-02-5

Grant and Affiliation Information for Comparison between a single dose of goserelin (depot) and multiple daily doses of leuprolide acetate for pituitary suppression in IVF treatment: a clinical endocrinological study of the ovarian response.

AFFILIATION: ORIGEN, Centro de Medicina Reprodutiva, Belo Horizonte, Minas Gerais, Brazil. sjgeber@bhnet.com.br

Country: United States

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MEDLINETA: J Assist Reprod Genet

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