[Comparative study of drug efficacy and drug additives between generic drugs and original drugs]

[Comparative study of drug efficacy and drug additives between generic drugs and original drugs] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Comparative study of drug efficacy and drug additives between generic drugs and original drugs] Abstract Text:

Hiromi Katoh,Michiko Yoshii,Koichiro Ozawa,Hiromi Katoh,Michiko Yoshii,Koichiro Ozawa,Hiromi Katoh,Michiko Yoshii,Koichiro Ozawa,

In the present study, we tested three kinds of sleeping drugs, consisting mainly of triazolam, brotizolam, and flunitrazepam, to compare the drug efficacy of generic drugs with that of original drugs. After these drugs were administered orally to mice, drug efficacy was evaluated in terms of ambulation, onset time of sleep, and duration of sleep in the open field test. For all kinds of sleep-inducing drugs, the drug efficacy of most generic drugs is not necessarily equal to that of the original drug. The main reason for the difference appears to be due to differences in the rate of absorption of the main drug. Any other differences between an original drug and a generic drug are caused by drug additives, the crystal form of the main drug, the formulation, and so on. In this study, the formulation was not the reason for the differences because all of the drugs were pulverized in a mortar and had no special coating. The drug additives for all the drugs are listed and the drug efficacy compared. Unfortunately, the information was not sufficient to shed any light on the differences in drug efficacy. For effective drug therapy, more information on drug additives should be provided.

[Comparative study of drug efficacy and drug additives between generic drugs and original drugs] Publishing Authors By Initials

H Katoh,M Yoshii,K Ozawa,H Katoh,M Yoshii,K Ozawa,H Katoh,M Yoshii,K Ozawa,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Comparative study of drug efficacy and drug additives between generic drugs and original drugs] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Yakugaku zasshi : Journal of the Pharmaceutical So

VOLUME: 127

Page Numbers: 2035-44

Journal Abbreviation: Yakugaku Zasshi

ISSN: 0031-6903

DAY: 6

MONTH: Dec

YEAR: 2007

[Comparative study of drug efficacy and drug additives between generic drugs and original drugs] Information

Number of References:

LANGUAGE: jpn

NlmUniqueID: 413613

[Comparative study of drug efficacy and drug additives between generic drugs and original drugs] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Comparative study of drug efficacy and drug additives between generic drugs and original drugs] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Comparative study of drug efficacy and drug additives between generic drugs and original drugs]

AFFILIATION: Division of Clinical Pharmacotherapeutics Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami, Minami-Ku, Hiroshima 734-8553, Japan.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Yakugaku Zasshi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Comparative study of drug efficacy and drug additives between generic drugs and original drugs Related Publications

• A secure distribution method for digitized image scan using a two-step wavelet-based technique: A Telemedicine Case.
• Acyl-adenylate formation coupled with mitochondrial respiration.
• Adenosine diphosphatase in the electron transfer particle.
• Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development.
• Bisphosphonate incadronate inhibits maturation of ectopic bone induced by recombinant human bone morphogenetic protein 2.
• Bridging reagent for protein. I. The reaction of diisocyanates with lysine and enzyme proteins.
• Bridging reagent for protein. II. The reaction of N,N'-polymethylene-bis(iodoacetamide) with cysteine and rabbit muscle aldolase.
• Cerebellar infarction secondary to os odontoideum.
• Comparison of 4 MV photon surface dose among Varian, Siemens, and Elekta linear accelerators for tangential breast treatment: a phantom study.
• Contribution of glutamate transporter GLT-1 to removal of synaptically released glutamate at climbing fiber-Purkinje cell synapses.
• Duplication of the inferior vena cava associated with other variations.
• Esterification of adenosine monophosphate coupled with the respiration of heavy beef heart mitochondria.
• Facilitated activation of metabotropic glutamate receptors in cerebellar Purkinje cells in glutamate transporter EAAT4-deficient mice.
• Fibroblasts of spinal ligaments pathologically differentiate into chondrocytes induced by recombinant human bone morphogenetic protein-2: morphological examinations for ossification of spinal ligaments.
• Fluorescence changes in mitochondrial protein associated with energy state.
• Gene therapy using AAV.
• Leuprorelin acetate for female patients with newly diagnosed acute leukemia receiving chemotherapy.
• Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system.
• Macroscopic and histological findings in the healing process of inhalation injury.
• Mechanisms of immunomodulation by mesenchymal stem cells.
• Membrane properties of rat medial vestibular nucleus neurons in vivo.
• Morphological substrate of autonomic failure and neurohormonal dysfunction in multiple system atrophy: impact on determining phenotype spectrum.
• Occurrence of ubiquinone and rhodoquinone in parasitic nematodes, Metastrangylus elongatus and Ascaris lumbricoides var. suis.
• On the isolation of mitochondria with high respiratory control from guinea pig pancreas.
• Phosphorylation of bound adenosine monophosphate in the electron transfer particle.
• Soft X-ray multilayer beam splitters.
• The detection and visualization of brain tumors on T2-weighted MRI images using multiparameter feature blocks.
• The effect of phosphine on respiration of rat liver mitochondria.
• Vector-producing tumor-tracking multipotent mesenchymal stromal cells for suicide cancer gene therapy.
• [Comparative study of drug efficacy and drug additives between generic drugs and original drugs]