Comparative role of immunoglobulin A in protective immunity against the Bordetellae.

Comparative role of immunoglobulin A in protective immunity against the Bordetellae. Research Abstract Details 

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Comparative role of immunoglobulin A in protective immunity against the Bordetellae. Abstract Text:

Daniel N Wolfe,Girish S Kirimanjeswara,Elizabeth M Goebel,Eric T Harvill,

The genus Bordetella includes a group of closely related mammalian pathogens that cause a variety of respiratory diseases in a long list of animals (B. bronchiseptica) and whooping cough in humans (B. pertussis and B. parapertussis). While past research has examined how these pathogens are eliminated from the lower respiratory tract, the host factors that control and/or clear the bordetellae from the upper respiratory tract remain unclear. We hypothesized that immunoglobulin A (IgA), the predominant mucosal antibody isotype, would have a protective role against these mucosal pathogens. IgA(-/-) mice were indistinguishable from wild-type mice in their control and clearance of B. pertussis or B. parapertussis, suggesting that IgA is not crucial to immunity to these organisms. However, naïve and convalescent IgA(-/-) mice were defective in reducing the numbers of B. bronchiseptica in the upper respiratory tract compared to wild-type controls. Passively transferred serum from convalescent IgA(-/-) mice was not as effective as serum from convalescent wild-type mice in clearing this pathogen from the tracheae of naive recipient mice. IgA induced by B. bronchiseptica infection predominantly recognized lipopolysaccharide-containing O-antigen, and antibodies against O-antigen were important to bacterial clearance from the trachea. Since an IgA response contributes to the control of B. bronchiseptica infection of the upper respiratory tract, immunization strategies aimed at inducing B. bronchiseptica-specific IgA may be beneficial to preventing the spread of this bacterium among domestic animal populations.

Comparative role of immunoglobulin A in protective immunity against the Bordetellae. Publishing Authors By Initials

DN Wolfe,GS Kirimanjeswara,EM Goebel,ET Harvill,

For similar respiratory system: trachea research abstracts see: respiratory system: trachea research

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Comparative role of immunoglobulin A in protective immunity against the Bordetellae. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Infection and immunity

VOLUME: 75

Page Numbers: 4416-22

Journal Abbreviation: Infect. Immun.

ISSN: 0019-9567

DAY: 25

MONTH: 06

YEAR: 2007

Comparative role of immunoglobulin A in protective immunity against the Bordetellae. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 246127

Comparative role of immunoglobulin A in protective immunity against the Bordetellae. Keywords Mesh Terms:

KEYWORDS: Trachea

MESH TERMS: microbiology

Chemical & Substance for Abstract: Comparative role of immunoglobulin A in protective immunity against the Bordetellae. Information

Substance Name: O Antigens

Registry Number: 0

Grant and Affiliation Information for Comparative role of immunoglobulin A in protective immunity against the Bordetellae.

AFFILIATION: Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI053075

ACRONYM: AI

MEDLINETA: Infect Immun

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