Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery.

Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery. Abstract Text:

Rameshwar U Kadam,V M Kiran,Nilanjan Roy,

Homology model of Leishmania SIR2 shed new light on the ligand binding features of this enzyme. The molecular electrostatic potentials (MESP), the cavity depth analysis, and LmSIR2-hSIRT2 models' superposition suggested that the nicotinamide binding catalytic domain has several minor but potentially important structural differences. These differences could be exploited for designing antileishmanial compounds.

Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery. Publishing Authors By Initials

RU Kadam,VM Kiran,N Roy,

For similar chemical actions and uses: pharmacologic actions: therapeutic uses: anti-infective agents: antiparasitic agents: antiprotozoal agents: trypanocidal agents research abstracts see: chemical actions and uses: pharmacologic actions: therapeutic uses: anti-infective agents: antiparasitic agents: antiprotozoal agents: trypanocidal agents research

PUBMED ID PMID:

MEDLINE DATE:

Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 16

Page Numbers: 6013-8

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 18

MONTH: 09

YEAR: 2006

Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107377

Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery. Keywords Mesh Terms:

KEYWORDS: Trypanocidal Agents

MESH TERMS: metabolism

Chemical & Substance for Abstract: Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery. Information

Substance Name: Sirtuins

Registry Number: EC 3.5.1.-

Grant and Affiliation Information for Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery.

AFFILIATION: Centre of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Sector 67, S. A. S. Nagar, Punjab 160062, India.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Bioorg Med Chem Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery Related Publications

• A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors.
• Assembly of feline calicivirus-like particle and its immunogenicity.
• Calotropis procera latex extract affords protection against inflammation and oxidative stress in Freund's complete adjuvant-induced monoarthritis in rats.
• Community eye health care for leprosy patients in west bengal, India.
• Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery.
• Development of primordial follicles in the hamster: role of estradiol-17beta.
• Effector proteins translocated by Legionella pneumophila: strength in numbers.
• Emotional distress in women presenting for breast imaging.
• Enhancing antitumor immunity: combining IL-12 with TGFbeta1 antagonism.
• Evaluation of the clinical decisions made for 2-year-olds referred for speech and language therapy: a follow-up study.
• Explosive Force Production and Fractionated Reaction Time in Elderly Low and High Active Women: 974: June 2 10:45 AM - 11:00 AM.
• Explosive force and fractionated reaction time in elderly low- and high-active women.
• Expression of G protein-coupled receptor 30 in the hamster ovary: differential regulation by gonadotropins and steroid hormones.
• Glossal angiomyoma: Imaging findings and endovascular treatment.
• Glycemic control in critically ill patients effect of delay in insulin administration.
• Harlequin fetus.
• Magnesium, essential for base excision repair enzymes, inhibits substrate binding of N-methylpurine-DNA glycosylase.
• Molecular mechanism of insulin resistance.
• Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression.
• Oxidative DNA damage repair in mammalian cells: a new perspective.
• Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart.
• Profiles and correlates of aggressive behaviour among adults with intellectual disabilities.
• Six-year incidence of proteinuria in type 1 diabetic African Americans.
• Surface plasmon resonance as a time-resolved probe of structural changes in molecular films: considerations for correlating resonance shifts with adsorbate layer parameters.
• Survey of clinical engineering in developing countries and model for technology acquisition and diffusion.
• Technical aspects of online hemodiafiltration.
• Tocotrienols: the emerging face of natural vitamin E.
• Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine.
• Where people die: a multilevel approach to understanding influences on site of death in America.
• miRNA: licensed to kill the messenger.