Comparative measurements of immunoreactive renin, plasma renin activity and angiotensin II in human plasma.

Comparative measurements of immunoreactive renin, plasma renin activity and angiotensin II in human plasma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Comparative measurements of immunoreactive renin, plasma renin activity and angiotensin II in human plasma. Abstract Text:

A Morganti,L Turolo,E Pulazzini,A Zanchetti,

In human plasma samples we compared the values of renin activity, determined with a conventional enzymatic assay, with those of immunoreactive renin, determined with a new, direct immunoradiometric assay which employs highly specific monoclonal antibodies, and with those of angiotensin II; the comparative measurements of renin were carried out also in trypsin activated samples of nephric and anephric subjects. We found that, overall, there was a close relationship between renin activity and immunoreactive renin; however, this relationship was absent when the statistical analysis was restricted to plasmas with low or very low renin. We also found that, within a rather wide range of values, angiotensin II was more closely correlated with immunoreactive renin than with renin activity. Trypsin activation increased to a similar extent immunoreactive renin and renin activity in plasma of nephric and anephric subjects and, overall, the values of total renin obtained with the two assays were significantly correlated. The results of these comparative determinations indicate that, in general, the measurement of immunoreactive renin represents a valid alternative to that of renin activity and a reliable index of the activity of the renin-angiotensin system. In addition, studies with trypsin activation suggest that even in the anephric state human plasma contains an inactive enzyme convertible into an active form which has immunological properties similar to those of active renin.

Comparative measurements of immunoreactive renin, plasma renin activity and angiotensin II in human plasma. Publishing Authors By Initials

A Morganti,L Turolo,E Pulazzini,A Zanchetti,

For similar enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases: trypsin research abstracts see: enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases: trypsin research

PUBMED ID PMID:

MEDLINE DATE:

Comparative measurements of immunoreactive renin, plasma renin activity and angiotensin II in human plasma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 9

Page Numbers: 1367-81

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1987

Comparative measurements of immunoreactive renin, plasma renin activity and angiotensin II in human plasma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Comparative measurements of immunoreactive renin, plasma renin activity and angiotensin II in human plasma. Keywords Mesh Terms:

KEYWORDS: Trypsin

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Comparative measurements of immunoreactive renin, plasma renin activity and angiotensin II in human plasma. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Comparative measurements of immunoreactive renin, plasma renin activity and angiotensin II in human plasma.

AFFILIATION: Istituto di Clinica Medica IV, Università di Milano, Italy.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Exp Hypertens A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Comparative measurements of immunoreactive renin, plasma renin activity and angiotensin II in human plasma Related Publications

• Addition of urapidil or metoprolol to the treatment of hypertensive non-responders to nifedipine monotherapy: efficacy and metabolic effects. Italian Urapidil Study Group.
• Antihypertensive therapy in patients above age 60 with systolic hypertension. A progress report of the European Working Party on High Blood Pressure in the Elderly (EWPHE).
• Cardiac, renal and vascular complications in the diabetic patient.
• Cardiovascular consequences of hypertension: therapeutic effects on organ damage and on cardiovascular events.
• Cardiovascular effects of afferent renal nerve stimulation.
• Carotid baroreceptor reflex in normotensive and hypertensive subjects.
• Characteristics of an ideal antihypertensive therapy for elderly hypertensives.
• Choice of antihypertensive drugs in the European Society of Hypertension-European Society of Cardiology guidelines: specific indications rather than ranking for general usage.
• Comparative measurements of immunoreactive renin, plasma renin activity and angiotensin II in human plasma.
• Differences in reflex control of arterial pressure and renin release during head-up tilting in the cat.
• Editing a scientific journal: problems and challenges.
• Evaluation of a new non-invasive semiautomatic blood pressure monitoring device.
• Factors influencing the carotid baroreceptor response to pressure changes in a neck chamber.
• Hemodynamic and neural effects of urapidil and prazosin in essential hypertensives.
• Interplay of sino-aortic reflexes and haemodynamic changes during natural sleep in the cat.
• Introduction.
• Left ventricular hypertrophy regression with antihypertensive treatment: focus on Candesartan.
• Mechanisms of blood pressure variability in man.
• Metabolic syndrome and left ventricular hypertrophy in a general population. Results from the Gubbio Study.
• Prevalence of carotid atherosclerosis in hypertension: preliminary baseline data from the European Lacidipine Study on Atheroscelerosis (ELSA).
• Relationship between the hypotensive and renin-stimulating actions of diuretic therapy in hypertensive patients.
• Renin release and renal vasomotor changes during stimulation of the brain stem in the cat.
• Role of the renal nerves in renin release during suprarenal aortic stenosis in cats.
• Target blood pressure in elderly hypertensive patients: how low should you go?
• The antiatherogenic effects of antihypertensive drugs: experimental and clinical evidence.
• The sympathetic nervous system in human hypertension.
• Time course of the changes in active and cryoactivatable renin in response to acute stimuli before and after diuretic therapy in man.
• Urapidil in hypercholesterolemic hypertensive patients.
• Value of echocardiographic and ambulatory blood pressure monitoring in hypertension.
• [Not Available.]