Comparative in vitro study of six carbamazepine products.

Comparative in vitro study of six carbamazepine products. Research Abstract Details 

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Comparative in vitro study of six carbamazepine products. Abstract Text:

The purpose of present study was to evaluate commercial preparations of carbamazepine tablets with respect to drug release through a defined sequence of experiments using Minitab software. The compliance of products with respect to United States Pharmacopeia (USP) dissolution test and comparison of the products with respect to drug release in different dissolution conditions is reported in the present paper. The different dissolution conditions studied include dissolution medium (1% SLS in purified water, 0.1 N HCl), volume (900 and 1,000 ml), rpm (50 rpm, 75 rpm). Studies indicated that all six products complied with USP dissolution criteria. However, the extent of influence of dissolution conditions on drug release was varied among the products. Distinct dissolution profiles were observed and there was no correlation with disintegration time in certain products. The in vitro dissolution experimentation helped in identifying the discriminatory dissolution conditions and also the formulations that were unaffected with change of dissolution variables. In summary, commercial preparations of carbamazepine vary widely in their dissolution behavior in multi dissolution run experimentation. Identifying this behavior of the products was essential as an in vitro tool for screening a good and a bad formulation.

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Comparative in vitro study of six carbamazepine products. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AAPS PharmSciTech

VOLUME: 9

Page Numbers: 357-65

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ISSN: 1530-9932

DAY: 16

MONTH: 02

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, Andhra Pradesh, India.

Country: United States

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MEDLINETA: AAPS PharmSciTech

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