Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults.

Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults. Research Abstract Details 

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Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults. Abstract Text:

Robert B Belshe,Frances K Newman,Ken Wilkins,Irene L Graham,Elizabeth Babusis,Marian Ewell,Sharon E Frey,

The present study was undertaken with controls using equal doses ID and IM plus the standard full dose IM to assess the role of route of vaccine in immunogenicity of inactivated influenza vaccine. The study was a prospective, randomized, active-controlled, open label clinical trial conducted in healthy young adult outpatients to compare the effect of route (IM versus ID) on antibody responses to influenza vaccine. Volunteers received 3, 6 or 9 microg of vaccine by ID or IM route; 15 microg IM was also studied. Low doses of vaccine given by either route were almost as immunogenic as the standard 15 microg IM dose of influenza vaccine. ID route was not superior to IM vaccine at inducing antibodies. ID vaccine induced significantly more local inflammatory response than IM vaccine.

Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults. Publishing Authors By Initials

RB Belshe,FK Newman,K Wilkins,IL Graham,E Babusis,M Ewell,SE Frey,

For similar investigative techniques: chemistry, analytical: titrimetry research abstracts see: investigative techniques: chemistry, analytical: titrimetry research

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MEDLINE DATE:

Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Vaccine

VOLUME: 25

Page Numbers: 6755-63

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 26

MONTH: 07

YEAR: 2007

Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8406899

Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults. Keywords Mesh Terms:

KEYWORDS: Titrimetry

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults. Information

Substance Name: Influenza Vaccines

Registry Number: 0

Grant and Affiliation Information for Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults.

AFFILIATION: Saint Louis University Medical Center, St. Louis, MO 63110, United States. belsherb@slu.edu

Country: Netherlands

AGENCY: United States NIAID

GRANT: N01-AI-25464

ACRONYM: AI

MEDLINETA: Vaccine

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