Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV encephalitis model.

Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV encephalitis model. Research Abstract Details 

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Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV encephalitis model. Abstract Text:

K K Seino,M T Long,E P J Gibbs,R A Bowen,S E Beachboard,P P Humphrey,M A Dixon,M A Bourgeois,K K Seino,M T Long,E P J Gibbs,R A Bowen,S E Beachboard,P P Humphrey,M A Dixon,M A Bourgeois,

We used a severe challenge model that produces clinical West Nile virus (WNV) disease to test the efficacy of three commercially available equine WNV vaccines in horses. Twenty-four healthy, WNV-seronegative horses of varying ages and genders were placed, in random and blind manner, into three trial groups consisting of eight horses each; two horses in each group received (i) an inactivated WNV vaccine (K-WN), (ii) a modified-live vaccine (CP-WN) containing the WNV prM and E proteins expressed by a canarypox vector, (iii) a live-chimera vaccine (WN-FV) containing WNV prM and E proteins expressed in a YF17D vector, or (iv) a diluent control. Challenge by this model caused grave neurological signs, viremia, moderate to severe histopathologic lesions in the brain and spinal cord, and an outcome of 0% survivorship in all six control horses. In contrast, challenge in horses at between 28 days postvaccination with the chimera vaccine and 56 days postvaccination with the commercial inactivated or modified-live vaccine resulted in 100% survivorship (protection from the onset of WNV encephalitis and viremia). Horses vaccinated with the live-chimera vaccine showed significantly fewer clinical signs than did the control horses (P

Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV encephalitis model. Publishing Authors By Initials

KK Seino,MT Long,EP Gibbs,RA Bowen,SE Beachboard,PP Humphrey,MA Dixon,MA Bourgeois,KK Seino,MT Long,EP Gibbs,RA Bowen,SE Beachboard,PP Humphrey,MA Dixon,MA Bourgeois,

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Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV encephalitis model. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical and vaccine immunology : CVI

VOLUME: 14

Page Numbers: 1465-71

Journal Abbreviation: Clin. Vaccine Immunol.

ISSN: 1556-6811

DAY: 8

MONTH: 08

YEAR: 2007

Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV encephalitis model. Information

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LANGUAGE: eng

NlmUniqueID: 101252125

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Grant and Affiliation Information for Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV encephalitis model.

AFFILIATION: College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL 32610, USA. seinok@mail.vetmed.ufl.edu

Country: United States

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MEDLINETA: Clin Vaccine Immunol

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