Comparative Antianaerobic Activities of Doripenem Determined by MIC and Time-Kill Analysis.

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Comparative Antianaerobic Activities of Doripenem Determined by MIC and Time-Kill Analysis. Abstract Text:

Kim L Credito,Lois M Ednie,Peter C Appelbaum,

Against 447 anaerobe strains, the investigational carbapenem doripenem had an MIC(50) of 0.125 mug/ml and an MIC(90) of 1 mug/ml. Results were similar to those for imipenem, meropenem, and ertapenem. Time-kill studies showed that doripenem had very good bactericidal activity compared to other carbapenems, with 99.9% killing of 11 strains at 2x MIC after 48 h.

Comparative Antianaerobic Activities of Doripenem Determined by MIC and Time-Kill Analysis. Publishing Authors By Initials

KL Credito,LM Ednie,PC Appelbaum,

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Comparative Antianaerobic Activities of Doripenem Determined by MIC and Time-Kill Analysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Antimicrobial agents and chemotherapy

VOLUME: 52

Page Numbers: 365-73

Journal Abbreviation: Antimicrob. Agents Chemother.

ISSN: 0066-4804

DAY: 15

MONTH: 10

YEAR: 2007

Comparative Antianaerobic Activities of Doripenem Determined by MIC and Time-Kill Analysis. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. pappelbaum@psu.edu.

Country: United States

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MEDLINETA: Antimicrob Agents Chemother

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