Comparative analysis of the effects of rice and bread meals on bioavailability of itraconazole using NONMEM in healthy volunteers.

Comparative analysis of the effects of rice and bread meals on bioavailability of itraconazole using NONMEM in healthy volunteers. Research Abstract Details 

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Comparative analysis of the effects of rice and bread meals on bioavailability of itraconazole using NONMEM in healthy volunteers. Abstract Text:

Hwi-yeol Yun,Min Sun Baek,In Sook Park,Bo Kyung Choi,Kwang-il Kwon,Hwi-yeol Yun,Min Sun Baek,In Sook Park,Bo Kyung Choi,Kwang-il Kwon,

OBJECTIVE: The objectives of this retrospective study were to examine the relationship between the bioavailability of itraconazole and the type of food consumed and to determine the effects of food consumption on the pharmacokinetic parameters following a single oral dose of itraconazole in healthy volunteers. METHODS: The plasma itraconazole concentration-time data were pooled from four pharmacokinetic studies in 144 healthy subjects. Individual pharmacokinetic values were estimated as model-independent (AUC, C (max), and T (max)) and model-dependent (T (lag), K (a), K (cp), K (pc), K (el), and V (d)/F; two-compartment open model with lag time) parameters using the WinNonlin software program. We estimated the population characteristics of the food effects using NONMEM. RESULTS: The consumption of a bread meal before the administration of itraconazole caused a significant increase in its bioavailability, as well as increases in the peak plasma concentration and lag time for itraconazole absorption. On the contrary, consumption of a rice meal before the administration of itraconazole caused a significant decrease in its bioavailability. CONCLUSION: Therefore, although a dose of itraconazole is normally administered immediately after a meal to increase its bioavailability, this is not an effective strategy after a rice meal.

Comparative analysis of the effects of rice and bread meals on bioavailability of itraconazole using NONMEM in healthy volunteers. Publishing Authors By Initials

HY Yun,MS Baek,IS Park,BK Choi,KI Kwon,HY Yun,MS Baek,IS Park,BK Choi,KI Kwon,

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Comparative analysis of the effects of rice and bread meals on bioavailability of itraconazole using NONMEM in healthy volunteers. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of clinical pharmacology

VOLUME: 62

Page Numbers: 1033-9

Journal Abbreviation: Eur. J. Clin. Pharmacol.

ISSN: 0031-6970

DAY: 20

MONTH: 10

YEAR: 2006

Comparative analysis of the effects of rice and bread meals on bioavailability of itraconazole using NONMEM in healthy volunteers. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Comparative analysis of the effects of rice and bread meals on bioavailability of itraconazole using NONMEM in healthy volunteers.

AFFILIATION: College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea.

Country: Germany

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MEDLINETA: Eur J Clin Pharmacol

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