Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda.

Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda. Research Abstract Details 

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Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda. Abstract Text:

Mahboobeh Safaeian,Mohammed Kiddugavu,Patti E Gravitt,Joseph Ssekasanvu,Dan Murokora,Marc Sklar,David Serwadda,Maria J Wawer,Keerti V Shah,Ron Gray,

OBJECTIVE: The objective of this study was to compare human papillomavirus (HPV) DNA testing between self-administered vaginal swabs and physician-administered cervical swabs in women from rural Rakai District, Uganda. STUDY DESIGN: Between 2002 and 2003, women from a population-based cohort participated in an HPV study. Women collected self-administered vaginal swabs and were also offered a pelvic examination, which included physician-collected cervical samples. METHODS: Hybrid-capture 2 was used to determine carcinogenic HPV status. Polymerase chain reaction was used to determine HPV genotypes. Unweighted kappa statistics were used to determine agreement. RESULTS: Compliance with self-collected swabs was > or =86%; however, only 51% accepted a pelvic examination. Carcinogenic HPV prevalence was 19% in self-collected and 19% in physician-collected samples. Agreement among paired observations was 92% with a kappa of 0.75. Kappa between self- and physician-collected samples was similar in HIV strata (k = 0.71 and 0.75 for HIV-positive and HIV-negative, respectively). DISCUSSION: In this community-based setting, detection of carcinogenic HPV was comparable among self- and physician-administered samples. Self-collection is a feasible and accurate means of obtaining HPV samples from women in resource-poor settings or persons reluctant to undergo a pelvic examination.

Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda. Publishing Authors By Initials

M Safaeian,M Kiddugavu,PE Gravitt,J Ssekasanvu,D Murokora,M Sklar,D Serwadda,MJ Wawer,KV Shah,R Gray,

For similar diagnosis: diagnostic techniques and procedures: diagnostic techniques, obstetrical and gynecological: vaginal smears research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic techniques, obstetrical and gynecological: vaginal smears research

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MEDLINE DATE:

Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Sexually transmitted diseases

VOLUME: 34

Page Numbers: 429-36

Journal Abbreviation:

ISSN: 0148-5717

DAY: 3

MONTH: Jul

YEAR: 2007

Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7705941

Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda. Keywords Mesh Terms:

KEYWORDS: Vaginal Smears

MESH TERMS: methods

Chemical & Substance for Abstract: Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda. Information

Substance Name: DNA, Viral

Registry Number: 0

Grant and Affiliation Information for Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda.

AFFILIATION: Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 20852, USA. safaeianm@mail.nih.gov

Country: United States

AGENCY: United States NIAID

GRANT: T32AI50056

ACRONYM: AI

MEDLINETA: Sex Transm Dis

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