Compact, high performance surface plasmon resonance imaging system.

Compact, high performance surface plasmon resonance imaging system. Research Abstract Details 

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Compact, high performance surface plasmon resonance imaging system. Abstract Text:

Timothy M Chinowsky,Michael S Grow,Kyle S Johnston,Kjell Nelson,Thayne Edwards,Elain Fu,Paul Yager,

We report the construction and characterization of a new compact surface plasmon resonance imaging instrument. Surface plasmon resonance imaging is a versatile technique for detection, quantification and visualization of biomolecular binding events which have spatial structure. The imager uses a folded light path, wide-field optics and a tilted detector to implement a high performance optical system in a volume 7 in. x 4 in. x 2 in. A bright diode light source and an image detector with fast frame rate and integrated digital signal processor enable real-time averaging of multiple images for improved signal-to-noise ratio. Operating angle of the imager is adjusted by linear translation of the light source. Imager performance is illustrated using resolution test targets, refractive index test solutions, and competition assays for the antiepileptic drug phenytoin. Microfluidic flowcells are used to enable simultaneous assay of three sample streams. Noise level of refractive index measurements was found to decrease proportional to the square root of the number of pixels averaged, reaching approximately 5 x 10(-7) refractive index units root-mean-square for 160 x 120 pixels image regions imaged for 1s. The simple, compact construction and high performance of the imager will allow the device to be readily applied to a wide range of applications.

Compact, high performance surface plasmon resonance imaging system. Publishing Authors By Initials

TM Chinowsky,MS Grow,KS Johnston,K Nelson,T Edwards,E Fu,P Yager,

For similar investigative techniques: chemistry, analytical: surface plasmon resonance research abstracts see: investigative techniques: chemistry, analytical: surface plasmon resonance research

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Compact, high performance surface plasmon resonance imaging system. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biosensors & bioelectronics

VOLUME: 22

Page Numbers: 2208-15

Journal Abbreviation:

ISSN: 0956-5663

DAY: 5

MONTH: 12

YEAR: 2006

Compact, high performance surface plasmon resonance imaging system. Information

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LANGUAGE: eng

NlmUniqueID: 9001289

Compact, high performance surface plasmon resonance imaging system. Keywords Mesh Terms:

KEYWORDS: Surface Plasmon Resonance

MESH TERMS: instrumentation

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Grant and Affiliation Information for Compact, high performance surface plasmon resonance imaging system.

AFFILIATION: timchinowsky@alum.mit.edu

Country: England

AGENCY: United States NIDCR

GRANT: U01DE14971-02

ACRONYM: DE

MEDLINETA: Biosens Bioelectron

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