Comorbid substance abuse and neurocognitive function in recent-onset schizophrenia.

Comorbid substance abuse and neurocognitive function in recent-onset schizophrenia. Research Abstract Details 

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Comorbid substance abuse and neurocognitive function in recent-onset schizophrenia. Abstract Text:

Thomas Wobrock,Helmut Sittinger,Bernd Behrendt,Roberto D'Amelio,Peter Falkai,Dieter Caspari,

Despite the high prevalence of comorbid substance use disorder (SUD) up to 65% in schizophrenia there is still few knowledge about the influence of substance abuse on neurocognitive function. In a prospective design we recruited 68 patients (aged 18-40 years) diagnosed as recent-onset schizophrenia or schizoaffective disorder consecutively admitted to hospital. The patients received standardized psychopathological evaluation of schizophrenic symptoms [Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS)], depressive symptoms [Montgomery Asberg Depression Rating Scale, (MADRS)] and global ratings [Clinical Global Impressions Scale (CGI), Global Assessment of Functioning Scale (GAF)]. Out of this sample 44 subjects underwent after stabilization (4-6 weeks after admission) neuropsychological investigation focusing on early information processing (Trail-Making-Test A, Digit Span), visuo-spatial ability (Corsi Block Tapping), verbal fluency (Verbal Fluency Test, semantic and letter category), and executive functioning and cognitive flexibility [Trail-Making-Test B, Wisconsin Card Sorting Test (WCST)]. About 36% of patients reported drug abuse [European Addiction Severity Index (EuropASI)] with a high prevalence for cannabis. Compared with nonabusers the sample of substance abusers was younger, predominantly male and had lower socioeconomic status. Attentional impairment according to the SANS subscale was less in abusers than in nonabusers on admission, no other psychopathological differences could be detected. Schizophrenic patients without substance abuse demonstrated significantly better performance only in a few neurocognitive tasks (Verbal Fluency, letter category and at trend level Digit Span, backwards), while there tended to be an advantage for substance abusers in executive functioning (WCST, not significant). These results are consistent with other studies of first-episode patients. The lack of higher cognitive disturbance in young schizophrenic patients with comorbid substance abuse may encourage clinicians to develop integrated treatment programmes using cognitive strategies of drug therapy.

Comorbid substance abuse and neurocognitive function in recent-onset schizophrenia. Publishing Authors By Initials

T Wobrock,H Sittinger,B Behrendt,R D'Amelio,P Falkai,D Caspari,

For similar disorders of environmental origin: substance-related disorders research abstracts see: disorders of environmental origin: substance-related disorders research

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Comorbid substance abuse and neurocognitive function in recent-onset schizophrenia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European archives of psychiatry and clinical neuro

VOLUME: 257

Page Numbers: 203-10

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ISSN: 0940-1334

DAY: 25

MONTH: 11

YEAR: 2006

Comorbid substance abuse and neurocognitive function in recent-onset schizophrenia. Information

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LANGUAGE: eng

NlmUniqueID: 9103030

Comorbid substance abuse and neurocognitive function in recent-onset schizophrenia. Keywords Mesh Terms:

KEYWORDS: Substance-Related Disorders

MESH TERMS: psychology

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Grant and Affiliation Information for Comorbid substance abuse and neurocognitive function in recent-onset schizophrenia.

AFFILIATION: Dept. of Psychiatry and Psychotherapy, University Hospital of Saarland, 66421 Homburg/Saar, Germany. thomas.wobrock@uniklinik-saarland.de

Country: Germany

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MEDLINETA: Eur Arch Psychiatry Clin Neuro

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