Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters.

Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters. Research Abstract Details 

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Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters. Abstract Text:

Edward Anthony Emmett,Hong Zhang,Frances Susan Shofer,David Freeman,Nancy Virginia Rodway,Chintan Desai,Leslie Michael Shaw,

OBJECTIVE: The objective of this study was to determine whether certain biomarkers of toxicity and/or a past diagnosis of liver or thyroid disease were associated with serum perfluorooctanoate concentrations (PFOA) in a community with longstanding environmental exposure to PFOA. METHODS: Serum (PFOA), hematologic and biochemical biomarkers, and a questionnaire were administered to 371 residents selected by stratified random sampling and a lottery among volunteers. Median PFOA was 354 ng/mL (interquartile range, 181-571 ng/mL). RESULTS: No significant positive relationships between serum (PFOA) and liver or renal function tests, cholesterol, thyroid-stimulating hormone, or with red cell indices, white cell, or platelet counts. Mean serum (PFOA) was not increased in those with a history of liver or thyroid disease. CONCLUSIONS: No toxicity from PFOA was demonstrated using the measured end points; other end points need to be addressed.

Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters. Publishing Authors By Initials

EA Emmett,H Zhang,FS Shofer,D Freeman,NV Rodway,C Desai,LM Shaw,

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Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of occupational and environmental medicine

VOLUME: 48

Page Numbers: 771-9

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ISSN: 1076-2752

DAY: 3

MONTH: Aug

YEAR: 2006

Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters. Information

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LANGUAGE: eng

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AFFILIATION: University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104-4284, USA. emmetted@mail.med.upenn.edu

Country: United States

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MEDLINETA: J Occup Environ Med

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