Communication systems in the genus Burkholderia: global regulators and targets for novel antipathogenic drugs.

Communication systems in the genus Burkholderia: global regulators and targets for novel antipathogenic drugs. Research Abstract Details 

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Communication systems in the genus Burkholderia: global regulators and targets for novel antipathogenic drugs. Abstract Text:

Pamela A Sokol,Rebecca J Malott,Kathrin Riedel,Leo Eberl,Pamela A Sokol,Rebecca J Malott,Kathrin Riedel,Leo Eberl,

The genus Burkholderia not only contains the primary pathogens Burkholderia pseudomallei and Burkholderia mallei but also several species that have emerged as opportunistic pathogens in persons suffering from cystic fibrosis or chronic granulomatous disease and immunocompromised individuals. Burkholderia species utilize quorum-sensing (QS) systems that rely on N-acyl-homoserine lactone (AHL) signal molecules to express virulence factors and other functions in a population-density-dependent manner. Most Burkholderia species employ the CepIR QS system, which relies on N-octanoyl-homoserine lactone. However, some strains harbour multiple QS systems and produce numerous AHLs. QS systems have been demonstrated to be essential for full virulence in various infection models and, thus, these regulatory systems represent attractive targets for the development of novel therapeutics.

Communication systems in the genus Burkholderia: global regulators and targets for novel antipathogenic drugs. Publishing Authors By Initials

PA Sokol,RJ Malott,K Riedel,L Eberl,PA Sokol,RJ Malott,K Riedel,L Eberl,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: quorum sensing research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: quorum sensing research

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Communication systems in the genus Burkholderia: global regulators and targets for novel antipathogenic drugs. Journal Published:

PUBLICATION TYPE: Review

Journal: Future microbiology

VOLUME: 2

Page Numbers: 555-63

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ISSN: 1746-0921

DAY: 27

MONTH: Oct

YEAR: 2007

Communication systems in the genus Burkholderia: global regulators and targets for novel antipathogenic drugs. Information

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LANGUAGE: eng

NlmUniqueID: 101278120

Communication systems in the genus Burkholderia: global regulators and targets for novel antipathogenic drugs. Keywords Mesh Terms:

KEYWORDS: Quorum Sensing

MESH TERMS: physiology

Chemical & Substance for Abstract: Communication systems in the genus Burkholderia: global regulators and targets for novel antipathogenic drugs. Information

Substance Name: Anti-Bacterial Agents

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Grant and Affiliation Information for Communication systems in the genus Burkholderia: global regulators and targets for novel antipathogenic drugs.

AFFILIATION: University of Calgary, Department of Microbiology and Infectious Diseases, Faculty of Medicine, 3330 Hospital Dr., NW Calgary, Alberta T2N 4N1, Canada. psokol@ucalgary.ca

Country: England

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MEDLINETA: Future Microbiol

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