Common evolutionary origin of the immune and neuroendocrine systems: from morphological and functional evidence to in silico approaches.

Common evolutionary origin of the immune and neuroendocrine systems: from morphological and functional evidence to in silico approaches. Research Abstract Details 

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Common evolutionary origin of the immune and neuroendocrine systems: from morphological and functional evidence to in silico approaches. Abstract Text:

Enzo Ottaviani,Davide Malagoli,Claudio Franceschi,Enzo Ottaviani,Davide Malagoli,Claudio Franceschi,

Ten years ago, we surmised that there was a common evolutionary origin for the immune and neuroendocrine systems. This was based on morphological and functional results indicating that a common pool of molecules is shared by the two systems, both in invertebrates and vertebrates. In the past decade, numerous molecular biology experiments have confirmed sequence similarity between invertebrate and vertebrate neuroimmune mediators, such as corticotrophin-releasing hormone. However, sequence similarity-based approaches were inadequate for analyzing other immune-related molecules, such as helical cytokines. This review covers older, and more recent findings on invertebrate immune- and neuroendocrine-related molecules with an evolutionary perspective, and suggests that protein-folding recognition algorithms are a fundamental tool in understanding the evolution of immune- and neuroendocrine-related molecules.

Common evolutionary origin of the immune and neuroendocrine systems: from morphological and functional evidence to in silico approaches. Publishing Authors By Initials

E Ottaviani,D Malagoli,C Franceschi,E Ottaviani,D Malagoli,C Franceschi,

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Common evolutionary origin of the immune and neuroendocrine systems: from morphological and functional evidence to in silico approaches. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Trends in immunology

VOLUME: 28

Page Numbers: 497-502

Journal Abbreviation: Trends Immunol.

ISSN: 1471-4906

DAY: 24

MONTH: 10

YEAR: 2007

Common evolutionary origin of the immune and neuroendocrine systems: from morphological and functional evidence to in silico approaches. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Common evolutionary origin of the immune and neuroendocrine systems: from morphological and functional evidence to in silico approaches.

AFFILIATION: Department of Animal Biology, University of Modena and Reggio Emilia, Via Campi 213/D, 41100 Modena, Italy.

Country: England

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MEDLINETA: Trends Immunol

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