Committed subcutaneous preadipocytes are reduced in human obesity.

Committed subcutaneous preadipocytes are reduced in human obesity. Research Abstract Details 

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Committed subcutaneous preadipocytes are reduced in human obesity. Abstract Text:

AIMS/HYPOTHESIS: The aim of this study was to test whether the availability of committed preadipocytes in abdominal and femoral subcutaneous adipose tissue varies with obesity and body fat distribution. METHODS: Body composition, fat cell size, committed preadipocytes and macrophages were measured in subcutaneous abdominal and femoral adipose depots of 17 lean, 16 upper-body-obese (UBO) and 13 lower-body-obese (LBO) women. Preadipocytes and macrophages were identified by simultaneous staining with the respective markers aP2 and CD68. In a subset of samples we measured preadipocyte proliferation, differentiation and susceptibility to apoptosis. RESULTS: Abdominal adipocytes were smaller in lean than in obese women. Committed preadipocytes represented a greater fraction of stromovascular cells in lean than in obese women but were similar between UBO and LBO women (abdomen: approximately 30 +/- 3 vs approximately 17 +/- 2%; thigh: approximately 30 +/- 3 vs approximately 17 +/- 2%). Preliminary data suggested that preadipocyte kinetics were similar in LBO and lean women, whereas preadipocytes of UBO women differentiated less and were more susceptible to apoptotic stimuli. The fraction of stromovascular cells that were macrophages was greater in both depots in obese women (UBO and LBO) than in normal-weight women, but the difference was not statistically significant. CONCLUSIONS/INTERPRETATION: The proportion of subcutaneous adipose tissue stromovascular cells that are committed preadipocytes is reduced with obesity. This could be due to greater recruitment of preadipocytes to adipogenesis or greater preadipocyte apoptosis, depending upon the obesity phenotype. These data are consistent with the concept that body fat distribution may be regulated partly through differences in adipogenesis.

Committed subcutaneous preadipocytes are reduced in human obesity. Publishing Authors By Initials

For similar body regions: extremities: lower extremity: thigh research abstracts see: body regions: extremities: lower extremity: thigh research

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Committed subcutaneous preadipocytes are reduced in human obesity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Diabetologia

VOLUME: 50

Page Numbers: 151-7

Journal Abbreviation: Diabetologia

ISSN: 0012-186X

DAY: 10

MONTH: 11

YEAR: 2006

Committed subcutaneous preadipocytes are reduced in human obesity. Information

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LANGUAGE: eng

NlmUniqueID: 6777

Committed subcutaneous preadipocytes are reduced in human obesity. Keywords Mesh Terms:

KEYWORDS: Thigh

MESH TERMS: pathology

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Grant and Affiliation Information for Committed subcutaneous preadipocytes are reduced in human obesity.

AFFILIATION: Endocrine Research Unit, 5-194 Joseph, Mayo Clinic, Rochester, MN, 55905, USA.

Country: Germany

AGENCY: United States NCRR

GRANT: RR00585

ACRONYM: RR

MEDLINETA: Diabetologia

REFSOURCE: Diabetologia. 2007 Jul;50(7):1569

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