Comments on the entropy-based transmission/disequilibrium test.

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Comments on the entropy-based transmission/disequilibrium test. Abstract Text:

Warren Ewens,Mingyao Li,Warren Ewens,Mingyao Li,

It has recently been claimed in this journal (Zhao et al. in Hum Genet 121:357-367, 2007) that a so-called "entropy-based" TDT test has improved power over the standard TDT test of Spielman et al. (Am J Hum Genet 52:506-516, 1993). We show that this claim is contradicted by standard statistical theory as well as by our simulation results. We show that the incorrect claim arises because of inappropriate assumptions, and also show that the entropy-based statistic has various undesirable properties.

Comments on the entropy-based transmission/disequilibrium test. Publishing Authors By Initials

W Ewens,M Li,W Ewens,M Li,

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Comments on the entropy-based transmission/disequilibrium test. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Human genetics

VOLUME: 123

Page Numbers: 97-100

Journal Abbreviation: Hum. Genet.

ISSN: 0340-6717

DAY: 30

MONTH: 11

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Biology, University of Pennsylvania, 324 Leidy Laboratories, Philadelphia, PA, 19104, USA, wewens@sas.upenn.edu.

Country: Germany

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MEDLINETA: Hum Genet

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