Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate.

Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate. Abstract Text:

Dev P Arya,Liang Xue,Paul Tennant,

Synthesis of a BQQ-neomycin conjugate is reported. The conjugate combines two ligands, one known to intercalate triplexes (BQQ) and another known to bind in the triplex groove (neomycin). The conjugate stabilizes T.A.T, as well as mixed base DNA triplex, better than neomycin, BQQ, or a combination of both. The conjugate selectively stabilizes the triplex (in the presence of physiological salt concentrations), with as little as 4 muM of the ligand leading to a DeltaTm of >60 degrees C. Competition dialysis studies show a clear preference for the drug binding to triplex DNA/RNA over the duplex/single strand structures. Modeling studies suggest a structure of neomycin bound to the larger W-H (Watson-Hoogsteen) groove with BQQ intercalated between the triplex bases.

Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate. Publishing Authors By Initials

DP Arya,L Xue,P Tennant,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research

PUBMED ID PMID:

MEDLINE DATE:

Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 8070-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 9

MONTH: Jul

YEAR: 2003

Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate. Keywords Mesh Terms:

KEYWORDS: RNA

MESH TERMS: metabolism

Chemical & Substance for Abstract: Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate.

AFFILIATION: Laboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC 29634, USA. dparya@clemson.edu

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Am Chem Soc

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate Related Publications

• Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection.
• CD34 expression by hair follicle stem cells is required for skin tumor development in mice.
• Carcinoma of the colon; a 10-year study.
• Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate.
• Comprehensive microarray transcriptome profiling of CD34-enriched mouse keratinocyte stem cells.
• Construct validity and reliability of the rivermead behavioural memory test in the Turkish population.
• Development and validation of a needs-based quality of life instrument for osteoarthritis.
• Goal attainment scaling: current methodological challenges.
• Hepatitis C, B, D, and A: contrasting features and liver function abnormalities in heroin addicts.
• Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infection.
• Internal construct validity of the Oxford Knee Scale: Evidence from Rasch measurement.
• Is experience as a prisoner of war a risk factor for accelerated age-related illness and disability?
• Measuring pain: issues of interpretation.
• Needed on voyage.
• Opioid serum concentrations in patients with chronic pain.
• Out of Programme Experience Auckland 2005.
• Preliminary observations on naltrexone for treatment of Alzheimer's type dementia.
• Psychological morbidity in Australian doctors who have and have not experienced a medico-legal matter: cross-sectional survey.
• Relapse following orthodontic rotation of teeth in dogs.
• Screening potential intakes of colour additives used in non-alcoholic beverages.
• Socio-demographic associations with social disablement in a community sample.
• The Neuropsychology of cannabis and other substance use in schizophrenia: review of the literature and critical evaluation of methodological issues.
• The development and validation of the Office Work Screen.
• The latest on e-prescribing.
• The neuropsychological correlates of cannabis use in schizophrenia: lifetime abuse/dependence, frequency of use, and recency of use.
• The role of the woodchuck model in the treatment of hepatitis B virus infection.
• The self-cleansing of soft-shell clams: bacteriological and public health aspects.
• Using compound kinoform hard-x-ray lenses to exceed the critical angle limit.
• Why not the private practice of addictionology?.
• Working with a brain injury: Personal experiences of returning to work following a mild or moderate brain injury.