Combined thyroidectomy and renal denervation suppress renin expression and secretion in fetal sheep.

Combined thyroidectomy and renal denervation suppress renin expression and secretion in fetal sheep. Research Abstract Details 

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Combined thyroidectomy and renal denervation suppress renin expression and secretion in fetal sheep. Abstract Text:

Kai Chen,Luke C Carey,Nancy K Valego,Jingfang Liu,James C Rose,

BACKGROUND AND OBJECTIVES: Activity of the fetal renin-angiotensin system (RAS) is developmentally regulated, increasing in late gestation toward term. Thyroid hormone and the renal nerves are both important modulators of renal RAS maturation; however, ablation of either influence alone does not totally block the aforementioned developmental late gestation increase in RAS in fetal sheep. In the current study, we used the technique of thyroidectomy combined with bilateral renal denervation (TX+D), which removes thyroid hormone from the circulation and abolishes effects of renal nerve activity, to determine if simultaneous removal of their effects on the kidney would markedly alter renin expression and secretion in late gestation. METHODS: TX+D was performed at 120 days of gestation age (dGA). Control fetuses were sham-operated. Immediately before necropsy (approximately 138 dGA), fetuses were infused with isoproterenol to examine plasma active and prorenin changes in response to beta-adrenergic stimulation. RESULTS: TX+D decreased plasma thyroid hormone concentrations, renal renin mRNA, renal active and prorenin levels, and plasma active and prorenin concentrations. Isoproterenol-induced increases in plasma active renin were also reduced in TX+D fetuses. TX+D did not alter renal angiotensin (Ang) II subtype receptor (AT2) expression close to term. CONCLUSION: These findings suggest that TX+D synergize in the suppression of fetal renin expression.

Combined thyroidectomy and renal denervation suppress renin expression and secretion in fetal sheep. Publishing Authors By Initials

K Chen,LC Carey,NK Valego,J Liu,JC Rose,

For similar surgical procedures, operative: endocrine surgical procedures: thyroidectomy research abstracts see: surgical procedures, operative: endocrine surgical procedures: thyroidectomy research

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Combined thyroidectomy and renal denervation suppress renin expression and secretion in fetal sheep. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of the Society for Gynecologic Investigati

VOLUME: 13

Page Numbers: 604-9

Journal Abbreviation: J. Soc. Gynecol. Investig.

ISSN: 1556-7117

DAY: 23

MONTH: 10

YEAR: 2006

Combined thyroidectomy and renal denervation suppress renin expression and secretion in fetal sheep. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9433806

Combined thyroidectomy and renal denervation suppress renin expression and secretion in fetal sheep. Keywords Mesh Terms:

KEYWORDS: Thyroidectomy

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Combined thyroidectomy and renal denervation suppress renin expression and secretion in fetal sheep. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Combined thyroidectomy and renal denervation suppress renin expression and secretion in fetal sheep.

AFFILIATION: Department of Obstetrics/Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1066, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD 17644

ACRONYM: HD

MEDLINETA: J Soc Gynecol Investig

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