Combined surgical excision and radiation therapy for keloid treatment.

Combined surgical excision and radiation therapy for keloid treatment. Research Abstract Details 

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Combined surgical excision and radiation therapy for keloid treatment. Abstract Text:

Sadanori Akita,Kozo Akino,Aya Yakabe,Toshifumi Imaizumi,Katsumi Tanaka,Kuniaki Anraku,Hiroki Yano,Akiyoshi Hirano,Sadanori Akita,Kozo Akino,Aya Yakabe,Toshifumi Imaizumi,Katsumi Tanaka,Kuniaki Anraku,Hiroki Yano,Akiyoshi Hirano,

Various methods have been attempted for the treatment and management of keloids; however, there is little satisfactory clinical evidence in long-term follow ups. Also, there is a preference for occurrence and recurrence in anatomic location. Usually anatomic locations with higher regional tension and more sebaceous glands are inclined toward pathogenesis. Thirty-eight keloids treated with combined surgical excision and postoperative irradiation, using electron beams with only a 10-mm opening by lead shielding, were investigated at a mean follow up of 4.4 +/- 2.5 years (range, 1-9 years) at a single institute. Ten locations such as the ear (n = 6), neck (n = 3), and upper lip (n = 1) were among the craniofacial locations. The hardness of the keloids and posttreatment scars was clinically and objectively tested with the Vancouver scar scale and a durometer, which is often used for the industrial measurement of thread balls and rubber. At a mean of 4.4 +/- 2.5 years of follow up, the clinical characteristics of the scars were significantly better posttreatment as 2.6 +/- 0.5 versus 1.0 +/- 0.6, 3.7 +/- 0.7 versus 1.7 +/- 0.7, 2.9 +/- 0.4 versus 1.3 +/- 0.5, and 2.7 +/- 0.5 versus 1.3 +/- 0.5 (keloid scars versus posttreatment scars: pigmentation, pliability, height and vascularity, respectively, P < 0.01). The durometer readings were significantly lower posttreatment, 15.2 +/- 3.9 versus 7.7 +/- 2.9 (keloid scars versus posttreatment scars, P < 0.01). The recurrence rate was 21.2% overall with none in craniofacial locations. Therefore, the combined treatment of surgical excision and postoperative electron beam irradiation is effective for scar quality and reducing the recurrence rate in long-term follow up.

Combined surgical excision and radiation therapy for keloid treatment. Publishing Authors By Initials

S Akita,K Akino,A Yakabe,T Imaizumi,K Tanaka,K Anraku,H Yano,A Hirano,S Akita,K Akino,A Yakabe,T Imaizumi,K Tanaka,K Anraku,H Yano,A Hirano,

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Combined surgical excision and radiation therapy for keloid treatment. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of craniofacial surgery

VOLUME: 18

Page Numbers: 1164-9

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ISSN: 1049-2275

DAY: 3

MONTH: Sep

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Combined surgical excision and radiation therapy for keloid treatment.

AFFILIATION: Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine, Nagasaki University, Graduate School of Biomedical and Sciences, Nagasaki, Japan. akitas@hf.rim.or.jp

Country: United States

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MEDLINETA: J Craniofac Surg

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