Combined Prognostic Value of Both RelA and IkappaB-alpha Expression in Human Non-Small Cell Lung Cancer.

Combined Prognostic Value of Both RelA and IkappaB-alpha Expression in Human Non-Small Cell Lung Cancer. Research Abstract Details 

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Combined Prognostic Value of Both RelA and IkappaB-alpha Expression in Human Non-Small Cell Lung Cancer. Abstract Text:

Dianliang Zhang,Xianqing Jin,Fuling Wang,Shan Wang,Chun Deng,Zongwei Gao,Chunbao Guo,Dianliang Zhang,Xianqing Jin,Fuling Wang,Shan Wang,Chun Deng,Zongwei Gao,Chunbao Guo,Dianliang Zhang,Xianqing Jin,Fuling Wang,Shan Wang,Chun Deng,Zongwei Gao,Chunbao Guo,

BACKGROUND: We sought to investigate the prognostic significance of nuclear factor (NF)-kappaB activity, especially nuclear RelA and IkappaB-alpha expression patterns, in non-small cell lung cancer (NSCLC). METHODS: A total of 116 patients with pathologically confirmed stage I to II NSCLC were included. Immunohistochemical analysis and electrophoretic mobility shift assays of NF-kappaB were performed to determine RelA and phosphorylated IkappaB-alpha staining, and DNA binding activity of NF-kappaB in human NSCLC. Downstream genes, including VEGF and IL-8, were also assessed. The prognostic significance of a single expression of RelA, phosphorylated IkappaB-alpha, and b-composite expressions was evaluated by Cox proportional hazard regression models and by Kaplan-Meier survival analyses. Correlation between RelA/IkappaB-alpha expression status and clinicopathological features of NSCLC was also analyzed. RESULTS: NF-kappaB DNA binding activity, VEGF, and IL-8 showed correlation with nuclear RelA and cytoplasmic pIkappaB-alpha expression. Expression of nuclear RelA/NF-kappaB showed an increase in NSCLC tissue compared with adjacent normal tissue and normal lung tissue. There was a positive correlation between NF-kappaB activation (nuclear translocation of RelA) and tumor clinicopathological features such as tumor grade, including T stages, N stages, and tumor, node, metastasis system stages, smoking status, and age. Positive correlation was observed between nuclear RelA and cytoplasmic pIkappaB-alpha. Both nuclear RelA and cytoplasmic pIkappaB-alpha were associated with poor prognosis by univariate and multivariate analyses. CONCLUSIONS: Nuclear RelA and cytoplasmic pIkappaB-alpha expression are associated with a poorer prognosis in NSCLC patients. In particular, composite application of these two biomarkers might be of greater value than application of a single marker to identify patients at high risk, even at an early clinical stage.

Combined Prognostic Value of Both RelA and IkappaB-alpha Expression in Human Non-Small Cell Lung Cancer. Publishing Authors By Initials

D Zhang,X Jin,F Wang,S Wang,C Deng,Z Gao,C Guo,D Zhang,X Jin,F Wang,S Wang,C Deng,Z Gao,C Guo,D Zhang,X Jin,F Wang,S Wang,C Deng,Z Gao,C Guo,

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Combined Prognostic Value of Both RelA and IkappaB-alpha Expression in Human Non-Small Cell Lung Cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of surgical oncology

VOLUME: 14

Page Numbers: 3581-92

Journal Abbreviation: Ann. Surg. Oncol.

ISSN: 1068-9265

DAY: 27

MONTH: 09

YEAR: 2007

Combined Prognostic Value of Both RelA and IkappaB-alpha Expression in Human Non-Small Cell Lung Cancer. Information

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LANGUAGE: eng

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AFFILIATION: Department of Surgery, Affiliated Hospital of Qingdao University, Qingdao, P.R. China.

Country: United States

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MEDLINETA: Ann Surg Oncol

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