Combined magnetic resonance imaging and bihemispheric magnetic resonance spectroscopy in acute experimental focal cerebral ischemia.

Combined magnetic resonance imaging and bihemispheric magnetic resonance spectroscopy in acute experimental focal cerebral ischemia. Research Abstract Details 

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Combined magnetic resonance imaging and bihemispheric magnetic resonance spectroscopy in acute experimental focal cerebral ischemia. Abstract Text:

R M Levy,I Berry,M E Moseley,P R Weinstein,

Combined magnetic resonance imaging (MRI) and 31P-magnetic resonance spectroscopy (MRS) were employed to evaluate acute regional cerebral ischemia in cats following middle cerebral artery occlusion (MCAO). MRI changes were first reliable 3 hours after MCAO; progressive increases in T1 and T2 relaxation times were noted for 12 hours after MCAO. Immediately after MCAO, 31P-MRS revealed decreased phosphocreatine (PCr) and increased inorganic phosphate (Pi); the PCr/Pi ratio fell from 2.23 +/- 0.40 to 0.68 +/- 0.04 (p less than 0.005). This relative decrease in high energy phosphates improved significantly by 3-5 hours after MCAO (0.67 +/- 0.04 versus 1.00 +/- 0.03, p less than 0.001). By 12 hours, the ratio had increased by 27 per cent. The dissociation between the progressive MRI changes and the gradual improvement in 31P-MRS suggests a difference between the processes affecting proton distribution and phosphate metabolism in acute regional ischemia.

Combined magnetic resonance imaging and bihemispheric magnetic resonance spectroscopy in acute experimental focal cerebral ischemia. Publishing Authors By Initials

RM Levy,I Berry,ME Moseley,PR Weinstein,

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Combined magnetic resonance imaging and bihemispheric magnetic resonance spectroscopy in acute experimental focal cerebral ischemia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta radiologica. Supplementum

VOLUME: 369

Page Numbers: 507-11

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ISSN: 0001-6926

DAY: 20

MONTH: 02

YEAR: 1986

Combined magnetic resonance imaging and bihemispheric magnetic resonance spectroscopy in acute experimental focal cerebral ischemia. Information

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LANGUAGE: eng

NlmUniqueID: 370370

Combined magnetic resonance imaging and bihemispheric magnetic resonance spectroscopy in acute experimental focal cerebral ischemia. Keywords Mesh Terms:

KEYWORDS: Male

MESH TERMS: diagnostic use

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Grant and Affiliation Information for Combined magnetic resonance imaging and bihemispheric magnetic resonance spectroscopy in acute experimental focal cerebral ischemia.

AFFILIATION: Department of Neurologic Surgery, University of California School of Medicine, San Francisco 94143.

Country: SWEDEN

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MEDLINETA: Acta Radiol Suppl

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