Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves.

Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves. Abstract Text:

Hnin Thidarmyint,Hiroko Yoshida,Tetsuya Ito,Maolong He,Hiroaki Inoue,Hideto Kuwayama,Hnin ThidarMyint,Hiroko Yoshida,Tetsuya Ito,Maolong He,Hiroaki Inoue,Hideto Kuwayama,Hnin ThidarMyint,Hiroko Yoshida,Tetsuya Ito,Maolong He,Hiroaki Inoue,Hideto Kuwayama,

Ghrelin is a gut peptide which participates in growth regulation through its somatotropic, lipogenic and orexigenic effects. Synergism of ghrelin and growth hormone-releasing hormone (GHRH) on growth hormone (GH) secretion has been reported in humans and rats, but not in domestic animals in vivo. In this study, effects of a combination of ghrelin and GHRH on plasma GH and other metabolic parameters, and changes in plasma active and total ghrelin levels were studied in Holstein bull calves before and after weaning. Six calves were intravenously injected with vehicle (0.1% BSA-saline), ghrelin (1mug/kg BW), GHRH (0.25mug/kg BW) or a combination of ghrelin plus GHRH at the age of 5 weeks and 10 weeks (weaning at 6 weeks of age). Ghrelin stimulated GH release with similar potency as GHRH and their combined administration synergistically stimulated GH release in preweaning calves. After weaning, GH responses to ghrelin and GHRH became greater compared with the values of preweaning calves, but a synergistic effect of ghrelin and GHRH was not observed. The GH areas under the concentration curves for 2h post-injection were greater in weaned than in preweaning calves (P<0.05) if ghrelin or GHRH were injected alone, but were similar if ghrelin and GHRH were injected together. Basal plasma active and total ghrelin levels did not change around weaning, but transiently increased after ghrelin injection. Basal plasma insulin, glucose and non-esterified fatty acid levels were reduced after weaning, but no changes by treatments were observed. In conclusion, ghrelin and GHRH synergistically stimulated GH release in preweaning calves, but this effect was lost after weaning.

Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves. Publishing Authors By Initials

H Thidarmyint,H Yoshida,T Ito,M He,H Inoue,H Kuwayama,H ThidarMyint,H Yoshida,T Ito,M He,H Inoue,H Kuwayama,H ThidarMyint,H Yoshida,T Ito,M He,H Inoue,H Kuwayama,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Domestic animal endocrinology

VOLUME: 34

Page Numbers: 118-23

Journal Abbreviation: Domest. Anim. Endocrinol.

ISSN: 0739-7240

DAY: 26

MONTH: 12

YEAR: 2006

Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8505191

Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves.

AFFILIATION: Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-11, Inada, Obihiro 080-8555, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Domest Anim Endocrinol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves Related Publications

• A case of iatrogenic cerebral infarction demonstrated by postmortem cerebral angiography.
• Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves.
• Effect of symptomatic gastroesophageal reflux disease on quality of life of patients with chronic liver disease.
• In vitro fertilization and development of bovine oocytes recovered from the ovaries of individual donors: A comparison between the cutting and aspiration method.
• Measurement of serum branched-chain amino acids to tyrosine ratio level is useful in a prediction of a change of serum albumin level in chronic liver disease.
• Preparation of myosin subfragment-1 from pig cardiac muscle myosin by chymotryptic digestion.
• Protective effect of n-3 polyunsaturated fatty acid on primary culture of rat hepatocytes.
• Role for des-acyl ghrelin in the responsiveness of plasma hormones and metabolites to ghrelin in Holstein steers.
• Separation of two different heavy meromyosins. Evidence for the presence of myosin isozymes in rabbit skeletal muscle.
• [Classification and diagnosis of intracranial dural arteriovenous fistulas]